Implication of the expression of retinoic acid-inducible gene-I in human glomerulonephritis

视黄酸诱导基因-I在人肾小球肾炎中表达的意义

• 批准号: 22591175
• 负责人: TANAKA Hiroshi
• 金额: $ 2.25万
• 依托单位: Hirosaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591175/
• 关键词: 小児腎; 泌尿器科学; 小児腎・泌尿器科学; レチノイン酸誘導遺伝子アイ; Retinoic acid-inducible gene-I; polyinosinic-polycytidylic acid; 培養ヒトメサンギウム細胞; Toll-like receptor 3; Interferon stimulated gene 20; 培養ヒトメサンギム細胞; Toll-like receptor3; CC chemokine ligand5; interferon-β

Viral infections may trigger the development of inflammatory renal disease or the worsening of pre-existing renal disease. Viral double-stranded RNA (dsRNA) can activate not only toll-like receptors (TLR) 3 located within intracellular endosomes and retinoic acid-inducible gene-I (RIG-I)-like helicase receptors located within the cytosol. RIG-I and melanoma differentiation-associated gene-5 (MDA5) are members of the RNA helicase family in the cytosol, and both act as pathogen recognition receptors. The activation of TLRs and their downstream immune responses can be induced by both infectious pathogens and non-infectious stimuli such as endogenous ligands, and this mechanism may be involved in the pathogenesis of autoimmune renal diseases. Based on our recent experimental studies using cultured normal human mesangial cells (MCs), we found that novel TLR3/RIG-I-mediated signaling pathways in MCs may be involved in the pathogenesis of glomerular diseases.

病毒感染可能引发炎症性肾病的发展或原有肾病的恶化。病毒双链RNA（dsRNA）不仅可以激活位于细胞内内体内的Toll样受体（TLR）3，还可以激活位于细胞质内的视黄酸诱导基因-I（RIG-I）样解旋酶受体。 RIG-I 和黑色素瘤分化相关基因 5 (MDA5) 是细胞质中 RNA 解旋酶家族的成员，两者都充当病原体识别受体。感染性病原体和内源性配体等非感染性刺激均可诱导TLRs的激活及其下游免疫反应，这种机制可能参与自身免疫性肾病的发病机制。基于我们最近使用培养的正常人系膜细胞（MC）进行的实验研究，我们发现MC中新的TLR3/RIG-I介导的信号通路可能参与肾小球疾病的发病机制。

项目成果

タクロリムスを基盤としたより非侵襲的なループス腎炎の治療

基于他克莫司的狼疮性肾炎更多无创治疗

• 发表时间: 2012
• 作者: 篠原 麻由;齊藤 真木子;山中 岳;雨宮馨;久保田 雅也;山形 崇倫;菊池 健二郎;川脇 寿;亀井 淳;赤坂 真奈美;安西 有紀;塩見 正司;水口 雅.;田中 完
• 通讯作者: 田中 完

Long-Term Tacrolimus-Based Immunosuppressive Treatment for Young Patients with Lupus Nephritis: A Prospective Study in Daily Clinical Practice

• DOI: 10.1159/000346149
• 发表时间: 2012-01-01
• 期刊: NEPHRON CLINICAL PRACTICE
• 作者: Tanaka, Hiroshi;Watanabe, Shojiro;Ito, Etsuro
• 通讯作者: Ito, Etsuro

培養ヒトメサンギウム細胞におけるretinoic acid-inducible gene-Iの発現とCCL5 : RANTESの制御

视黄酸诱导基因-I在培养的人系膜细胞中的表达和CCL5的调节：RANTES

• 发表时间: 2010
• 作者: Sekimizu M;Sunami S;Nakazawa A;Hayashi Y;Okimoto Y;Saito AM;Horibe K;Tsurusawa M;Mori T.;田中完
• 通讯作者: 田中完

培養ヒトメサンギウム細胞におけるretinoic acid-inducible gene-I の発現とCCL5 : RANTES の制御

视黄酸诱导基因-I在培养的人系膜细胞中的表达和CCL5的调节：RANTES

• 发表时间: 2010
• 作者: Oki K;Takita J;Hiwatari M;Nishimura R;Sanada M;Okubo J;Adachi M;Sotomatsu M;Kikuchi A;Igarashi T;Hayashi Y;Ogawa S.;田中 完,敦賀和志,沖 栄真,相澤知美
• 通讯作者: 田中 完,敦賀和志,沖 栄真,相澤知美

Novel multidrug therapy for children with cyclosporine-resistant or -intolerant nephrotic syndrome

• DOI: 10.1007/s00467-011-1876-z
• 发表时间: 2011-08-01
• 期刊: PEDIATRIC NEPHROLOGY
• 影响因子: 3
• 作者: Aizawa-Yashiro, Tomomi;Tsuruga, Kazushi;Tanaka, Hiroshi
• 通讯作者: Tanaka, Hiroshi