Steroid-resistant mechanism in smoking asthma

吸烟哮喘的类固醇抵抗机制

• 批准号: 22591097
• 负责人: MATSUNAGA Kazuto
• 金额: $ 2.75万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591097/
• 关键词: 気管支喘息; 喫煙; 気道炎症; 閉塞性障害; 気道過敏性; 酸化ストレス; 窒素化ストレス; ステロイド; 臨床免疫学; 炎症関連物質; 慢性閉塞性肺疾患; 活性酸素種; 活性窒素種; アレルギー性鼻炎

Smoking habit is an important contributor to difficult asthma. Oxidative/nitrative stress induced by smoking is assumed to be a cause of the airway remodeling. This research has demonstrated that the smoking history is an independent risk factor for persistent bronchial inflammation in steroid-treated asthma. Furthermore, our study suggested that peroxynitrite can influence tissue remodeling by promoting matrix metaloproteases release, while theophylline suppresses peroxynitrite-induced tissue remodeling via pathways involving NF-kB and/or HDAC in the fibroblasts.

吸烟习惯是困难哮喘的重要贡献者。假定吸烟引起的氧化/硝化应激被认为是气道重塑的原因。这项研究表明，吸烟史是类固醇治疗的哮喘中持续支气管炎症的独立危险因素。此外，我们的研究表明，过氧亚硝酸盐可以通过促进基质金属蛋白酶释放来影响组织重塑，而Theophiphline抑制过氧亚硝酸盐诱导的组织通过涉及NF-KB和/或HDAC的途径中的过氧亚硝酸盐诱导的组织重塑。

项目成果

免疫・アレルギー-高齢者喘息と耳鼻咽喉科-

免疫学/过敏 - 老年哮喘和耳鼻喉科 -

• 发表时间: 2012
• 期刊: JOHNS
• 作者: 山本夏男;三浦里織;高橋実;藤田禎三;大花昇;今福裕司;細川裕之;中山俊憲;山本秀輝;川上和義;賀来満夫;金光敬二;松永和人
• 通讯作者: 松永和人

Thematic Poster Session:Validation of a compact accelerometer for the measurement of physical activity in patients with COPD

主题海报会议：验证用于测量慢性阻塞性肺病患者体力活动的紧凑型加速度计

• 发表时间: 2011
• 作者: Y. Minakata;A. Sugino;M. Nishigai;M.Kanda;K. Akamatsu;A. Koarai;T. Hirano;H. Sugiura;K. Matsunaga;M. Ichinose
• 通讯作者: M. Ichinose

Developing obstructive change over time is dominant in small airways in severe asthma

随着时间的推移，严重哮喘患者的小气道发生阻塞性变化占主导地位

• 作者: Kanayama A;Iyoda T;Matsuzaki K;Saika T;Ikeda F;Ishii Y;Yamaguchi K and Kobayashi I;Matsunaga K;Matsunaga K
• 通讯作者: Matsunaga K

Thematic Poster Session:Increase of 25-hydroxycholesterol in the lungs of chronic obstructive pulmonary disease

主题海报会议：慢性阻塞性肺病患者肺部 25-羟基胆固醇升高

• 发表时间: 2011
• 作者: H. Sugiura;A. Koarai;T . Ichikawa;Y. Minakata;K. Matsunaga;T. Hirano;K. Akamatsu;S. Yanagisawa;M. Furusawa;Y. Uno;M. Yamasaki;M.Ichinose
• 通讯作者: M.Ichinose

Thematic poster session: Increased27-hydroxycholesterol Production In The Airways Of Chronic ObstructivePulmonary Disease

主题海报会议：慢性阻塞性肺疾病气道中 27-羟基胆固醇的产生增加

• 发表时间: 2011
• 作者: T. Kikuchi;H. Sugiura;A. Koarai;T. Ichikawa;Y. Minakata;K. Matsunaga;M. Nakanishi;T. Hirano;K. Akamatsu;S. Yanagisawa;K. Furukawa;M. Kanda;H. Kawabata;M. Ichinose
• 通讯作者: M. Ichinose