Investigations on development of pulmonary arterial intimal sarcoma and identification and isolation of hematopoietic stem cells

肺动脉内膜肉瘤发生发展及造血干细胞鉴定分离的研究

• 批准号: 22590851
• 负责人: SAKAO Seiichiro
• 金额: $ 3.08万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590851/
• 关键词: 非閉塞性肺疾患癌; 肺動脈原発血管内肉腫; 肺線維症; 呼吸器感染症

We have investigated sarcoma-like cells (SCLs) derived from endarterectomized tissue from chronic thromboembolic pulmonary hypertension (CTEPH). The characteristic features of SCLs showed that these cells appeared to be pulmonary arterial intimal sarcoma. Because of the increased expression of mRNAs of matrixmethalloproteinase (MMPs), anti-tumor effects of MMPs inhibitors (batimastat) were examined. Batimastat inhibited cell proliferation, invasion, migration, and tube-formation of SCLs. Moreover, batimastat inhibited the growth of subucutanenous tumor and weight loss of the mice. These results indicate that MMPs inhibitors seem to be effective against some types of intimal sarcoma. Previous study suggested that SCLs might include some kinds of hematopoietic stem cells, but isolation of these cells would be future directions.

我们已经研究了从慢性血栓栓塞肺动脉高压（CTEPH）衍生自内膜组织的肉瘤样细胞（SCL）。 SCL的特征表明，这些细胞似乎是肺动脉内膜肉瘤。由于基质甲甲蛋白酶（MMP）的mRNA表达增加，因此检查了MMP抑制剂（Batimastat）的抗肿瘤作用。 Batimastat抑制了SCLS的细胞增殖，侵袭，迁移和管形成。此外，巴丁氏菌抑制了亚t肿的肿瘤的生长和小鼠的体重减轻。这些结果表明，MMP抑制剂似乎对某些类型的内膜肉瘤有效。先前的研究表明，SCL可能包括某种造血干细胞，但是这些细胞的隔离将是未来的方向。

项目成果

Association of deep vein thrombosis type with clinical phenotype of chronic thromboembolic pulmonary hypertension

• DOI: 10.1016/j.ijcard.2011.08.851
• 发表时间: 2013-05-25
• 期刊: INTERNATIONAL JOURNAL OF CARDIOLOGY
• 影响因子: 3.5
• 作者: Kantake, Masashi;Tanabe, Nobuhiro;Tatsumi, Koichiro
• 通讯作者: Tatsumi, Koichiro

Mixed venous oxygen tension affects the prognosis on pulmonary hypertension even in recent Era

即使在近代，混合静脉氧压仍影响肺动脉高压的预后

• 发表时间: 2012
• 作者: Sekine A;Tanabe N;Sakao S;Nishimura R;Terada J;Sugiura T;Kasahara Y;Tatsumi K
• 通讯作者: Tatsumi K

Right ventricle volume index and right ventricle to left ventricular volume ratio by electrocardiogram-gated 320 slice CT is a predictor of right ventricular pressure load in pulmonary hypertension

心电图门控 320 层 CT 的右心室容积指数和右心室与左心室容积比是肺动脉高压右心室压力负荷的预测因子

• 发表时间: 2012
• 作者: Sugiura T;Tanabe N;Kawata N;Matsuura Y;Yanagawa N;Kasai H;Kasahara Y;Sakao S;Tatsumi K
• 通讯作者: Tatsumi K

Right ventricle volume index and right ventricle to left ventricular volume ratio by electrocardiogram-gated 320 slice CT is a predictor of right ventricular pressure load in pulmonary hypertension.

心电图门控 320 层 CT 得出的右心室容积指数和右心室与左心室容积比是肺动脉高压右心室压力负荷的预测因子。

• 发表时间: 2012
• 作者: Sugiura T;Tanabe N;Kawata N;Matsuura Y;Yanagawa N;Kasai H;Kasahara Y;Sakao S;Tatsumi K.
• 通讯作者: Tatsumi K.

Serum Level of Fibrinogen Aα Chain Fragment Increases in Chronic Thromboembolic Pulmonary Hypertension

慢性血栓栓塞性肺动脉高压患者血清纤维蛋白原 Aα 链片段水平升高

• 发表时间: 2011
• 期刊: Circ J
• 影响因子: 3.3
• 作者: Yano T;Sogawa K;Umemura H;Sakao S;Kasahara Y;Tanabe N;Kodera Y;Takiguchi Y;Tatsumi K;Nomura F
• 通讯作者: Nomura F