Role of neutrophil mediated inflammatory reactions in the development of bovine dry-period mastitis caused by Staphylococcus aureus intramammary infection

中性粒细胞介导的炎症反应在金黄色葡萄球菌乳腺感染引起的牛干期乳腺炎中的作用

• 批准号: 22580347
• 负责人: WATANABE Atsushi
• 金额: $ 3万
• 依托单位: National Agriculture and Food Research Organization
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22580347/
• 关键词: 乳牛; 乳房炎; 黄色ブドウ球菌; 好中球; インターロイキン-8; エラスターゼ; ラクトフェリン由来ペプチド; 乾乳期乳房炎; 細胞外トラップ; ロイコシジン; 獣医学; 感染症; 免疫学; 生体分子; 動物

The dry period bovine mastitis caused by Staphylococcus aureus infection shows characteristic pathogenesis that is lastingly developed. We showed that interleukin-8 (IL-8), leukocyte elastase, and inflammatory lactoferrin-derived peptides were released, in relation with the pathogenesis of S. aureus dry period mastitis, in mastitic mammary secretions. In the chronic stage of the mastitis, transforming growth factor-β2 that suppresses IL-8 secretion was suggested to be involved in subsiding of the inflammation.

干燥时期的牛乳腺炎引起的脑膜感染显示了近来发育的炭态发病机理。在乳腺炎的慢性阶段，乳腺炎改变了生长因子-β2，该因子β2提示IL -8 cretion参与炎症累积。

项目成果

牛由来黄色ブドウ球菌に特有な病原因子lukM/LukF'-PVは牛貪食細胞に強い細胞傷害性を示す

LukM/LukF-PV是牛金黄色葡萄球菌特有的致病因子，对牛吞噬细胞表现出强烈的细胞毒性

• 发表时间: 2012
• 作者: 秦英司;渡部淳;塩野浩紀;内田郁夫;高松大輔
• 通讯作者: 高松大輔

ブドウ球菌ロイコシジンならびにγヘモリシンの牛由来細胞に対する細胞傷害能の解析

葡萄球菌杀白细胞素和γ-溶血素对牛源细胞的细胞毒能力分析

• 发表时间: 2012
• 作者: 秦英司;渡部淳;塩野浩紀;内田郁夫;高松大輔
• 通讯作者: 高松大輔

Production of bovine transforming growth factor beta 1 following stimulation with lipopolysaccharide

脂多糖刺激后牛转化生长因子β1的产生

• 发表时间: 2012
• 作者: Slama;P. ;Zbysek;S.;Slamova;R.;Pavlik;A.;Zdenek;H.;Jiri;S. and Watanabe;A
• 通讯作者: A

Possible involvement of transforming growth factor-beta2 in the development of bovine dry period mastitis induced by intramammary infusion of Staphylococcus aureus

转化生长因子-β2 可能参与乳房内输注金黄色葡萄球菌引起的牛干奶期乳腺炎的发生

• 发表时间: 2013
• 作者: Watanabe;A.;Hata;E.;Hirota;J.;Shimizu;S.;Kadota;K;Slama;P.;Chikayama;Y.;Ishikawa;Y. and Kimura;K
• 通讯作者: K

Cytotoxicity of the staphylococcal leukocidins on bovine cells

葡萄球菌杀白细胞素对牛细胞的细胞毒性

• 发表时间: 2011
• 作者: Hata;E.;Watanabe;A.;Uchida;I.,Tanaka;K.;Tamamura;Y. and Takamatsu;D
• 通讯作者: D