Establishment of objective evaluation of medication effect for Attention-deficit/hyperactivity disorder with near-infrared spectroscopy.

近红外光谱客观评价注意力缺陷/多动障碍药物疗效的建立

• 批准号: 21791129
• 负责人: YOSHIKAWA Toru
• 金额: $ 1.33万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791129/
• 关键词: 注意欠陥多動性障害; 近赤外線分光法(NIRS); 薬物療法; 前頭葉機能; 近赤外線分光法（NIRS）; 自閉症スペクトラム障害

The number of children given a diagnosis of attention-deficit/hyperactivity disorder(ADHD) increases year by year in Japan. And methylphenidate(MPH) is often prescribed to treat individuals diagnosed with ADHD. The development of a simple and convenient effect measurement method of MPH is demanded. Ten children with ADHD under MPH medication participated in the present study. The relative concentrations of oxyhemoglobin(oxy-Hb) and deoxyhemoglobin(deoxy-Hb) were measured with frontal probes during the continuous performance test(CPT), using a NIRS machine. Compared with the off-MPH condition, mean reaction time is shorter and the number of omission error is smaller in the on-MPH condition. During the CPT, the oxy-Hb were significantly larger and deoxy-Hb were slightly larger than baseline in the bilateral frontal probes. But there is no statistically significant difference between on-and off-MPH conditions. The large individual differences of NIRS signal and small number of cases are the limitations. It will be necessary to increase number of cases in future study.

在日本，被诊断为注意力缺陷/多动障碍（ADHD）的儿童数量逐年增加。哌醋甲酯 (MPH) 通常用于治疗被诊断患有多动症的患者。需要开发一种简单、方便的 MPH 效果测量方法。十名接受 MPH 药物治疗的 ADHD 儿童参与了本研究。在连续性能测试 (CPT) 过程中，使用 NIRS 机器通过额探头测量氧合血红蛋白 (oxy-Hb) 和脱氧血红蛋白 (deoxy-Hb) 的相对浓度。与关闭 MPH 条件相比，开启 MPH 条件下的平均反应时间更短，遗漏错误次数更小。在 CPT 期间，双侧额探头的氧合血红蛋白明显大于基线，脱氧血红蛋白略大于基线。但开启和关闭 MPH 条件之间没有统计学上的显着差异。 NIRS信号的个体差异较大且病例数较少是其局限性。未来的研究有必要增加案例数量。

项目成果

Hemodynamic changes in the prefrontal cortex during digit span task

数字跨度任务期间前额皮质的血流动力学变化

• 发表时间: 2011
• 期刊: A near-infrared spectroscopy study Neuropsychobiology
• 作者: Kaneko H;Yoshikawa T;Nomura K;Ito H;Yamauchi H;Ogura M;Honjo S
• 通讯作者: Honjo S

Prefrontal activation, autonomic arousal and task performance under mental pressure

精神压力下的前额叶激活、自主神经唤醒和任务表现

• 发表时间: 2009
• 作者: Yamauchi Hoshiko;Ito Hiroyuki;Yoshikawa Toru;Nomura Kenji;Kaneko Hitoshi
• 通讯作者: Kaneko Hitoshi

Psychiatric Problems of Children in Residing in Children's Care Home in Japan.Symposium 4 (open) International Symposium : Global Perspectives on Child Protection and Children's Rights

日本儿童保育院儿童的精神问题研讨会4（公开）国际研讨会：儿童保护和儿童权利的全球视角

• 发表时间: 2011
• 作者: Toru Yoshikawa;Kenji Nomura;Hitoshi Kaneko;Shuji Honio;Satomi Murase
• 通讯作者: Satomi Murase

Hitoshi Kaneko HEMODYNAMIC ACTIVATION IN INFANTS' PREFRONTAL AND OCCIPITAL CORTICES WHEN VIEWING MATERNAL FACIAL EXPRESSIONS

Hitoshi Kaneko 观察母亲面部表情时婴儿前额叶和枕叶皮质的血流动力学激活

• 发表时间: 2011
• 作者: Hiroko Yamamoto;Toru Yoshikawa;Hiroyuki Ito;Kenji Nomura;Kazuhiro Yasunaga
• 通讯作者: Kazuhiro Yasunaga

コメント付き動画視聴時における脳血流の検討-近赤外線分光法を用いて-

在观看带评论的视频期间检查脑血流量 - 使用近红外光谱 -

• 发表时间: 2011
• 作者: Toru Yoshikawa;Kenji Nomura;Hitoshi Kaneko;Shuji Honio;Satomi Murase;安永和央,吉川徹,伊藤大幸,山内星子,小倉正義,野邑健二,金子一史;山脇彩,吉川徹,伊藤大幸,小倉正義,野邑健二,山内星子,金子一史
• 通讯作者: 山脇彩,吉川徹,伊藤大幸,小倉正義,野邑健二,山内星子,金子一史