The role of Olig genes in mental retardation of Down syndrome

Olig基因在唐氏综合症智力低下中的作用

• 批准号: 21791019
• 负责人: TAKAKI Eiichi
• 金额: $ 2.83万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791019/
• 关键词: ダウン症候群; 精神発達遅滞; オリゴデンドロサイト

Down's syndrome (DS), which is characterized by mental retardation and typical facies, is caused by whole or partial trisomy of HSA21. However, the pathological mechanism of DS is unclear. We focused Olig genes as candidates of the causal genes of DS. Our observation suggests that Olig genes are one of the causal genes of multiple phenotypes in DS, such as mental retardation and abnormal oligodendrogenesis.

唐氏综合症（DS）的特征是精神降低和典型的相，是由HSA21的全部或部分三体造成的。但是，DS的病理机制尚不清楚。我们将寡核基因作为DS因果基因的候选物。我们的观察结果表明，olig基因是DS中多种表型的因果基因之一，例如智力低下和异常的寡构成。