Characterization of abortion related factor of intracellular protozoan parasite Neospora caninum and its application for vaccine development

细胞内原生动物寄生虫犬新孢子虫流产相关因子的表征及其在疫苗开发中的应用

• 批准号: 21780262
• 负责人: NISHIKAWA Yoshifumi
• 金额: $ 2.91万
• 依托单位: Obihiro University of Agriculture and Veterinary Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21780262/
• 关键词: 寄生虫; 原虫; ワクチン; 流産; 垂直感染; 家畜原虫病; 家畜の流産; ネオスポラ; 免疫; 寄生虫; 原虫; ワクチン; 流産; 垂直感染; 家畜原虫病; 家畜の流産; ネオスポラ; 免疫

The aim of this study is to characterize an abortion related factor of Neospora caninum, NcGRA7, for development of vaccine against neosporosis. This study showed that NcGRA7 could stimulate immune cells. Moreover, we developed vaccine based on NcGRA7 and could control the parasite infection in mouse model. The present study indicates the positive results for the vaccine development against neosporosis.

这项研究的目的是表征新孢子虫（NCGRA7）的堕胎因子，以开发针对新孢子症的疫苗。这项研究表明NCGRA7可以刺激免疫细胞。此外，我们基于NCGRA7开发了疫苗，可以控制小鼠模型中的寄生虫感染。本研究表明，针对新孢子症的疫苗发育的阳性结果。