Expression of Permeability-glycoprotein (P-gp) and Uptake of Technetium-99m-Hexakis-2-Methoxy-Isobutyl-Isonitrile (Tc-99m-MIBI) in Malignant Tumor of the Head and Neck

头颈部恶性肿瘤中渗透性糖蛋白(P-gp)的表达和Technetium-99m-Hexakis-2-甲氧基异丁基异腈(Tc-99m-MIBI)的摄取

基本信息

  • 批准号:
    13671972
  • 负责人:
  • 金额:
    $ 0.64万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2001
  • 资助国家:
    日本
  • 起止时间:
    2001 至 2003
  • 项目状态:
    已结题

项目摘要

(Clinical evaluation) As for the retention index (delayed uptake / early uptake), 99m-Tc-MIBI showed the retention index of under 1 (mean ± SD = 0.853 ± 0.067) in malignant tumor, indicating a tendency of decreasing in the delayed uptake. On the other hand, the retention indexes of 201-TlCl scintigraphy were classified into three groups according to histopathological types of tumor ; 0.81 ± 0.06 in benign tumors, 1.01 ± 0.10 in well differentiated malignant tumors, 1.09 ± 0.13 in moderately differentiated tumors, and 1.24 ± 0.14 in poorly differentiated tumors. Thus, the mean retention indexes were under 1 in benign tumor, but over 1 in malignant tumor. The higher the histopathological grade was, the larger the retention index became.(Accumulation mechanism) As for the relationship between P-gp expression (score 0, 1 and 2) and histopathological type of tumor, the scores (mean ± SD) = 0.75 ± 0.19 in benign tumors, 0.71 ± 0.36 in well differentiated tumor, 0.83 ± 0.40 in moderately differentiated tumor, and 1.60 ± 0.24 in poorly differentiated tumor. Thus, the mean score of P-gp expression was small in the benign or low-grade malignant tumor, but large in the high-grade malignant tumors. Comparing of Na, K-ATPase expression (score 0, 1 and 2) to the histopathological type of tumor, the scores (mean) = 0.82 in well differentiated tumor, 1.44 in moderately differentiated tumor, and 1.50 in poorly differentiated tumors respectively.(Conclusion) 99m-Tc-MIBI and 201-TlCl scintigraphy showed different tendency of delayed uptake, and accurate diagnosis of tumor could be obtained by using both 99m-Tc-MIBI and 201-TlCl scintigraphy. P-gp and Na, K-ATPase expression were observed in accordance with the results of 99m-Tc-MIBI and 201-TlCl scintigraphy.
(临床评价)对于保留指数(延迟摄取/早期摄取),99m-Tc-MIBI在恶性肿瘤中显示保留指数低于1(平均值±SD=0.853±0.067),表明延迟摄取有降低的趋势。另一方面,201-TlCl闪烁显像的保留指数根据肿瘤的组织病理学类型分为三组。良性肿瘤中为0.81±0.06,高分化恶性肿瘤中为1.01±0.10,中分化肿瘤中为1.09±0.13,低分化肿瘤中为1.24±0.14。因此,平均保留指数在良性肿瘤中低于1,但在低分化肿瘤中高于1。恶性肿瘤组织病理学分级越高,保留指数越大。 (积累机制)至于P-gp表达(得分0、1和2)与肿瘤组织病理学类型之间的关系,良性肿瘤中得分(平均值±SD)=0.75±0.19,高分化肿瘤中0.71±0.36中分化肿瘤为 0.83 ± 0.40,低分化肿瘤为 1.60 ± 0.24。因此,与 Na、K-ATPase 表达(得分 0、1 和 2)相比,P-gp 表达的平均得分在良性或低度恶性肿瘤中较小,但在高度恶性肿瘤中较大。肿瘤的组织病理学类型,高分化肿瘤的得分(平均值)= 0.82,中分化肿瘤的得分(平均值)= 1.44,低分化肿瘤的得分(平均值)= 1.50 (结论) 99m-Tc-MIBI和201-TlCl闪烁显像显示不同的延迟摄取趋势,同时使用99m-Tc-MIBI和201-TlCl闪烁显像和P-gp可以得到准确的肿瘤诊断。根据 99m-Tc-MIBI 和 201-TlCl 闪烁扫描结果观察 ATPase 表达。

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Sato.T et al.: "Dynamic Scintigraphy with thallium-201 chloride(Tl-201) for the diagnosis of tumors of the head and neck"Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 92. 228-235 (2001)
Sato.T 等人:“使用 201 氯化铊 (Tl-201) 进行动态闪烁扫描,用于诊断头颈部肿瘤”Oral Surg Oral Med Oral Pathol Oral Radiol Endod。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Sato, T, et al.: "Dynamic scintigaphy with thallium-201-chloride (TlCl-201) for the diagnosis of tumors of the head and neck"Oral Surg Oral Med Oral Pathol Oral Radial Endod (Mosby Inc). 92, 2. 226-235 (2001)
Sato, T 等人:“使用 201-氯化铊 (TlCl-201) 进行动态闪烁检查,用于诊断头颈部肿瘤”Oral Surg Oral Med Oral Pathol Oral Radial Endod (Mosby Inc)。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Sato, T., et al.: "Dynamic scintigraphy with thallium-201-chloride (TlCl-201) for the diagnosis of tumors of the head and neck"Oral Sur Oral Med Oral Pathol Oral Radiol Endod. 92. 226-235 (2001)
Sato, T. 等人:“使用 201-氯化铊 (TlCl-201) 进行动态闪烁扫描,用于诊断头颈部肿瘤”Oral Sur Oral Med Oral Pathol Oral Radiol Endod。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
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SATO Tsuyoshi其他文献

SATO Tsuyoshi的其他文献

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{{ truncateString('SATO Tsuyoshi', 18)}}的其他基金

Molecular mechanisms of nerve-vessel-bone network
神经-血管-骨网络的分子机制
  • 批准号:
    26293432
  • 财政年份:
    2014
  • 资助金额:
    $ 0.64万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Functional analysis of melanocortin receptor agonists in bone metabolism and the possibility of clinical application for osteonecrosis of the jaw
黑皮质素受体激动剂骨代谢功能分析及临床应用治疗颌骨坏死的可能性
  • 批准号:
    23592941
  • 财政年份:
    2011
  • 资助金额:
    $ 0.64万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Scintigraphic imaging system of micro-metastasis of lymph node with pinhole collimator
针孔准直器淋巴结微转移闪烁显像系统
  • 批准号:
    20592206
  • 财政年份:
    2008
  • 资助金额:
    $ 0.64万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Does semaphorin regulate differentiation and network among cells in osteocyte?
信号蛋白是否调节骨细胞中细胞之间的分化和网络?
  • 批准号:
    20791544
  • 财政年份:
    2008
  • 资助金额:
    $ 0.64万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Analysis of Angiogenesis for the Intra-Articular Lesions of Temporomandibular Joint Disorders by Mechanical Stress
机械应力引起的颞下颌关节疾病关节内病变的血管生成分析
  • 批准号:
    10671773
  • 财政年份:
    1998
  • 资助金额:
    $ 0.64万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Histologic and Hydrodynamic Evaluation of Blood Flow for Scintigraphic Detection of Malignant Tumor of the Head and Neck.
头颈部恶性肿瘤闪烁显像检测中血流的组织学和流体动力学评估。
  • 批准号:
    07672052
  • 财政年份:
    1995
  • 资助金额:
    $ 0.64万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

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  • 批准号:
    07770745
  • 财政年份:
    1995
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  • 批准号:
    04770774
  • 财政年份:
    1992
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