Breast Cancer Diagnosis by Optical Imaging with Inverse Problem of Source Estimation

利用源估计逆问题的光学成像诊断乳腺癌

• 批准号: 21760312
• 负责人: OKAWA Shinpei
• 金额: $ 1.75万
• 依托单位: The University of Electro-Communications
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21760312/
• 关键词: 信号処理; 逆問題; 拡散光トモグラフィ; 蛍光トモグラフィ; 乳がん

The algorithms to solve the inverse problems in the optical imaging using near-infrared light for diagnoses of breast cancer were studied. The technique for reconstructing fluorescent light sources in biological media by use of spatial filter was proposed. The method to reduce noise in the time-resolved measurement data using maximum a priori estimation was also developed. The proposed methods were validated with the numerical simulations and the phantom experiments. Efficient arrangement of the light sources and detectors for diffuse optical tomography was also investigated.

研究了使用近红外光在光学成像中解决乳腺癌的算法。提出了通过使用空间过滤器在生物介质中重建荧光光源的技术。还开发了使用最大先验估计的时间分辨测量数据中噪声的方法。通过数值模拟和幻影实验对所提出的方法进行了验证。还研究了光源和检测器的有效布置弥漫性光学断层扫描。

项目成果

Reduction of Poisson noise in measured time-resolved data for time-domain diffuse optical tomography

• DOI: 10.1007/s11517-011-0774-7
• 发表时间: 2011
• 期刊: Medical & Biological Engineering & Computing
• 影响因子: 3.2
• 作者: S. Okawa;Y. Endo;Y. Hoshi;Yukio Yamada

3次元拡散光トモグラフィのシミュレーション

3D 漫射光学断层扫描模拟

• 发表时间: 2010
• 作者: Tomoyoshi Shimobaba;Nobuyuki Masuda;Yasuyuki Ichihashi;Tomoyoshi Ito;内田和浩
• 通讯作者: 内田和浩

Reduction of Poisson Noise for Time-Resolved Diffuse Optical Measurement

时间分辨漫反射光学测量中泊松噪声的降低

• 发表时间: 2010
• 作者: S.Okawa;Y.Yamada
• 通讯作者: Y.Yamada

Effect of the Arragngement of Optodes for 3D Diffuse Optical Tomography

3D漫射光学层析成像的光极排列效果

• 发表时间: 2011
• 作者: K.Uchida;S.Okawa;K.Masamoto;Y.Hoshi;Y.Yamada
• 通讯作者: Y.Yamada

3D light source reconstruction with spatial filter for fluorescence/bioluminescence diffuse optical tomography

使用空间滤波器重建 3D 光源，用于荧光/生物发光漫射光学断层扫描

• 发表时间: 2009
• 作者: Tomoyoshi Shimobaba;Junya Miura;Tomoyoshi Ito;Takashi SATO;Shinpei Okawa
• 通讯作者: Shinpei Okawa