Elucidation brain functional network of by temporal and spatial correlation analysis of ECoG and application for brain-machine interface

ECoG时空相关性分析阐明脑功能网络及脑机接口应用

基本信息

批准号：
21390406
负责人：
KAMADA Kyousuke
金额：
$ 7.9万
依托单位：
Asahikawa Medical College
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2011
项目状态：
已结题

项目摘要

For careful interpretation of spatial and temporal changes of electrocorticogram (ECoG) with semantic tasks, we developed a software to visualize semantic-ECoG dynamics on individual brain. Twenty patients underwent implantation of subdural electrodes (more than 80 channels) bilaterally for diagnostic purpose of intractable epilepsy. Semantic-ECoG was recorded with word, figure and face recognition and memory tasks. The ECoG raw data was processed by averaging and time-frequency analysis and the functional profiles were projected on individual brain surface. Acquired ECoG was classified by Support Vector Machine and Sparse Logistic Regression to decode brain signals. Because of variations of electrode locations, we normalized the ECoG elecrtodes using SPM8. The basal temporal-occipital cortex was activated within 250 msec after visual object presentations. Face stimulation evoked significantly higher ECoG amplitudes than other stimuli. The hipocumpus was dominantly activated than other brain areas by the memory task. Prediction rate od ECoG-classification reached 90%, which was sufficient for clinical use. Semantic-ECoG is a powerful technique to detect and decode the human brain functions.

为了仔细解释具有语义任务的电代理图（ECOG）的空间和时间变化，我们开发了一种软件来可视化单个大脑上的语义-ECOG动力学。有20名患者双侧接受了硬膜下电极（超过80个通道），以进行顽固性癫痫的诊断目的。使用单词，图形和面部识别和内存任务记录语义模型。通过平均和时频分析来处理ECOG原始数据，功能曲线投影在单个大脑表面上。获得的ECOG由支持向量机和稀疏逻辑回归分类以解码大脑信号。由于电极位置的变化，我们使用SPM8将ECOG Elecrtodes归一化。在视觉对象表现后，在250毫秒内激活了基础颞枕皮质。与其他刺激相比，面部刺激引起的ECOG振幅明显更高。通过记忆任务，Hipocumpus比其他大脑区域主要激活。预测率OD生态型分类达到90％，这足以容纳临床使用。语义模型是检测和解码人脑功能的强大技术。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Tractographyと白質機能マッピングによる脳腫瘍手術

使用纤维束成像和白质功能图谱进行脑肿瘤手术

DOI：
发表时间：
2010
期刊：
Medical Science Digest
影响因子：
0
作者：
Umeki A;Nishimura T;Takewa Y;Ando M;Mizuno T;Tsukiya T;Kyo S;Taenaka Y;Ono M;Tatsumi E;野崎和彦;夏目敦至;鎌田恭輔
通讯作者：
鎌田恭輔

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