In vivo whole-cell recording analysis of response properties of vestibular nucleus neuron to head rotation

前庭核神经元对头部旋转反应特性的体内全细胞记录分析

• 批准号: 21300147
• 负责人: SAITO Yasuhiko
• 金额: $ 12.31万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21300147/
• 关键词: 前庭神経核; 眼球運動; 膜特性; パッチクランプ; 舌下神経前位核; ニューロン; シナプス; 前庭動眼反射; ラット; 求心性入力

We investigated the response properties of neurons in the medial vestibular nucleus (MVN) to head rotations using whole-cell recordings in in vivo preparations of rats. Most MVN neurons tested increased the firing frequency in response to the head rotation to the recording side. Furthermore, the neurons showed an afterhyperpolarization with dual components and a repetitive firing pattern with relatively constant interspike intervals. This finding suggests that MVN neurons that show specific intrinsic properties respond to the head rotation to a specific direction.

我们利用大鼠体内制剂的全细胞记录研究了内侧前庭核 (MVN) 神经元对头部旋转的反应特性。大多数测试的 MVN 神经元响应头部旋转到记录侧而增加了放电频率。此外，神经元表现出具有双重成分的后超极化和具有相对恒定的峰间间隔的重复放电模式。这一发现表明，表现出特定内在特性的 MVN 神经元会对头部向特定方向的旋转做出反应。

项目成果

Expression of Ca^<2+>-permeable AMPA receptors in rat prepositus hypoglossi nucleus neurons

大鼠舌前核神经元Ca^2-通透性AMPA受体的表达

• 发表时间: 2010
• 作者: Saito Y;Yanagawa Y
• 通讯作者: Yanagawa Y

Control of spontaneous firings by Ca^<2+>-activated ion channels triggered by the Ca^<2+> release via ryanodine receptors in inhibitory neurons in the rat prepositus hypoglossi nucleus

大鼠舌下核抑制性神经元中通过兰尼碱受体释放 Ca^2 触发的 Ca^2 激活离子通道对自发放电的控制

• 发表时间: 2011
• 作者: Saito Y;Yanagawa Y
• 通讯作者: Yanagawa Y

Characterization of ionic channels underlying the specific firing pattern of a novel neuronal subtype in the rat prepositus hypoglossi nucleus

大鼠舌下核新型神经元亚型特定放电模式下离子通道的表征

• 发表时间: 2012
• 期刊: Neuroscience Research
• 影响因子: 2.9
• 作者: Saito Y;Shino M;Yanagawa Y
• 通讯作者: Yanagawa Y

Activation of ryanodine receptors control spontaneous discharge of inhibitory neurons in the rat prepositus hypoglossi nucleus

兰尼碱受体的激活控制大鼠舌下核前部抑制性神经元的自发放电

• 发表时间: 2011
• 作者: Saito Y;Yanagawa Y
• 通讯作者: Yanagawa Y

Contribution of Ca^<2+>-permeable AMPA receptors to sustained activity in rat preoositus hypoglossi nucleus neurons.

Ca 2+ -渗透性AMPA受体对大鼠舌下核神经元前位持续活性的贡献。

• 发表时间: 2011
• 作者: Saito Y;Yanagawa Y
• 通讯作者: Yanagawa Y