Functional analyses of novel autophagy system in immune responses

新型自噬系统在免疫反应中的功能分析

• 批准号: 21200067
• 负责人: KURUSU Takamitsu
• 金额: $ 17.06万
• 依托单位: Tokyo University of Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21200067/
• 关键词: 病害抵抗性; 環境応答; オートファジー; 細胞内物流; 生殖; イネ; 感染防御; シグナル伝達; タンパク質リン酸化; カルシウムイオン; 免疫活性化剤; 植物; 病害抵抗性; 環境応答; オートファジー; 細胞内物流; 生殖; イネ; 感染防御; シグナル伝達; タンパク質リン酸化; カルシウムイオン; 免疫活性化剤; 植物

Our studies revealed that plant immune responses were regulated by both membrane traffic and degradation system. We also established the real-time monitoring system of autophagy in tobacco BY-2 cells as well as rice, and found the dynamic changes of autophagy during the induction of immune responses in plant cells. In addition, we identified several autophagy mutants (Osatgs) from rice, and functional analyses of mutants revealed that autophagy plays critical roles in during reproductive development in rice. We believe that these findings are useful for improving stress resistance in many crops.

我们的研究表明，植物免疫反应受膜交通和降解系统的调节。我们还建立了烟草By-2细胞和大米中自噬的实时监测系统，并发现自噬在诱导植物细胞中免疫反应期间的动态变化。此外，我们从水稻中确定了几种自噬突变体（OSATG），突变体的功能分析表明，自噬在水稻生殖发育过程中起着关键作用。我们认为，这些发现对于改善许多农作物的压力性很有用。