Analysis of Hematopoietic stem cell regulation through Polycomb-group complex 1

Polycomb 复合物 1 对造血干细胞的调节分析

• 批准号: 21602004
• 负责人: OHTSUBO Motoaki
• 金额: $ 3.08万
• 依托单位: Beppu University (2011)Hiroshima University (2009-2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21602004/
• 关键词: 再生医学; 発生・分化; 造血幹細胞; ポリコーム複合体; Geminin; DNA複製制御; DMA複製制御

We revealed that Polycomb-group(PcG) complex 1 regulates the protein's stability of Geminin either by directly acting as the E3 ubiquitin ligase or indirectly through transcriptional regulation of Hoxa9 and Hoxb4.Our observations will contribute to the development of a method to enhance hematopoietic stem cell activity by manipulating the E3 ubiquitin ligase activity of PcG complex 1 through the modification of Scmh1.

We revealed that Polycomb-group(PcG) complex 1 regulates the protein's stability of Geminin either by directly acting as the E3 ubiquitin ligase or indirectly through transcriptional regulation of Hoxa9 and Hoxb4.Our observations will contribute to the development of a method to enhance hematopoietic stem cell activity by manipulating the E3 ubiquitin ligase activity of PcG complex 1 through the modification of SCMH1。

项目成果

血液フロンティア・がん幹細胞研究の新たな展開・幹細胞における細胞周期制御

血液前沿/癌症干细胞研究新进展/干细胞的细胞周期调控

• 发表时间: 2012
• 作者: Ohtsubo;M.;Yasunaga;S.;Tsumura;M.;Ohno;Y.;Kageyama;Y.;Kimura;S.;Tokimoto;R.;Takihara;Y.;長谷真;瀧原義宏,安永晋一郎,大野芳典,大坪素秋
• 通讯作者: 瀧原義宏,安永晋一郎,大野芳典,大坪素秋

Overexpression of BMI-1 correlates with drug resistance in B-cell lymphoma cells through the stabilization of surviving expression

BMI-1 的过度表达通过稳定存活表达与 B 细胞淋巴瘤细胞的耐药性相关

• 发表时间: 2012
• 期刊: Cancer Science
• 影响因子: 5.7
• 作者: Bhattacharyya;J.;Mihara;K.;Ohtsubo;M.;Yasunaga;S.;Takei;Y.;Yanagihara;K.;Sakai;A.;Hishi;M.;Takihara;Y.;Kimura;A.
• 通讯作者: A.

Molecular pathogenesis of a novel mutation, G108D, in short-chain acyl-CoA dehydrogenase identified in subjects with short-chain acyl-CoA dehydrogenase deficiency

• DOI: 10.1007/s00439-010-0822-7
• 发表时间: 2010-06-01
• 期刊: HUMAN GENETICS
• 影响因子: 5.3
• 作者: Shirao, Kenichiro;Okada, Satoshi;Kobayashi, Masao
• 通讯作者: Kobayashi, Masao

Study of a 5-FU-induced stabilization signal for Scmh1, a component of Polycomb-group complex 1 E3 ligase

研究 5-FU 诱导的 Scmh1 稳定信号，Scmh1 是 Polycomb 基团复合物 1 E3 连接酶的一个组成部分

• 发表时间: 2009
• 作者: Ohtsubo;M.;Yasunaga;S.;Ohno;Y.;Tsumura;M.;Kageyama;Y.;Mori;S.;Takihara;Y.
• 通讯作者: Y.

Hole for an Scmh1-mediated molecular network governing Geminin expression in hematopoiesis

Scmh1 介导的造血过程中控制 Geminin 表达的分子网络的孔

• 发表时间: 2012
• 作者: Ohtsubo;M.;Yasunaga;Y.;Ohno;Y.;Kawashima;A.;Tetsuguchi;H.;Saeki;K;Nakashima;Y.;Takihara;Y.
• 通讯作者: Y.