RE MOUTH ACTIVITIES INVOLVED IN THE PROCESS OF COGNITIVE DISORDERS?-IN SEARCH OF NEUROPATHOLOGIC ASSOCIATIONS-

RE 口腔活动参与认知障碍的过程？-寻找神经病理学关联-

基本信息

批准号：
21592473
负责人：
NARITA Noriyuki
金额：
$ 2.25万
依托单位：
Nihon University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2011
项目状态：
已结题

项目摘要

Denture wearing is considered to improve chewing ability, chewing comfort, and quality of life(QOL) in elderly individuals. In order to clarify the effects of denture treatment on activation of the prefrontal cortex, which is involved in higher cognitive functions, we investigated the efficacy of wearing a denture prosthesis from the aspects of cognitive and jaw functions, and related prefrontal cortex activity. Partially edentulous patients were enlisted as subjects. Functional near infrared spectroscopy(f-NIRS) was used to detect changes of cerebral blood flow in the prefrontal cortex area, while cognitive functions were examined using questionnaires(SF36 v2, OHIP-J, and MMSE : Mini-mental state examination), with jaw muscle EMG and motions activities simultaneously investigated. Masticatory scores were also used to evaluate subjective awareness and consciousness of chewing ability. Statistical comparisons were performed between data obtained while wearing and not wearing a denture prosthesis. Significant increases were seen in chewing-related jaw functions, including jaw motion, jaw muscle EMG, and prefrontal cortex activity, while masticatory scores were also significantly improved by wearing a partial denture prosthesis as compared with the non-wearing condition. Prefrontal cortex activity caused by a wearing denture prosthesis was significantly related to masticatory score and masticatory EMG activities. During the process of denture treatment, the scores of dental and physical QOL, and MMSE showed improving trends as compared to the pre-therapeutic conditions. Based on our findings, we consider that dental treatment with a denture prosthesis may help to improve not only masticatory jaw functions, but also cognitive ability, as shown by prefrontal cortex activation and cognitive scores for oral and physical QOL.

佩戴假牙被认为可以提高老年人的咀嚼能力、咀嚼舒适度和生活质量 (QOL)。为了明确义齿治疗对参与高级认知功能的前额皮质激活的影响，我们从认知和颌功能以及相关的前额皮质活动方面研究了佩戴义齿修复体的功效。部分无牙颌患者被纳入研究对象。采用功能性近红外光谱（f-NIRS）检测前额叶皮层区域脑血流量的变化，同时采用问卷（SF36 v2、OHIP-J和MMSE：简易精神状态检查）检查认知功能，下颌肌肉肌电图和运动活动同时进行研究。咀嚼评分也用于评价咀嚼能力的主观意识和意识。对佩戴和不佩戴义齿修复体时获得的数据进行统计比较。与咀嚼相关的下颌功能显着增加，包括下颌运动、下颌肌肉肌电图和前额皮质活动，而与不佩戴条件相比，佩戴局部义齿修复体的咀嚼评分也显着改善。佩戴义齿修复体引起的前额皮质活动与咀嚼评分和咀嚼肌电图活动显着相关。在义齿治疗过程中，牙齿和身体QOL、MMSE评分较治疗前均呈现改善趋势。根据我们的研究结果，我们认为使用义齿修复体进行牙科治疗不仅有助于改善咀嚼颌功能，还有助于改善认知能力，如前额皮质激活以及口腔和身体生活质量的认知评分所示。