Treatment strategy for micro-lymph node metastases using anti-tumoral immunological mechanism

利用抗肿瘤免疫机制治疗微淋巴结转移的策略

• 批准号: 21591707
• 负责人: ISHIGAMI Sumiya
• 金额: $ 3.16万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591707/
• 关键词: リンパ節転移; 抗腫瘍免疫機構; リンパ節転移モデル; ケモカイン; HLA抗原; 抗腫瘍免疫寄稿; 抗腫瘍免疫; 微小転移; 転移モデル

We tried to clarify the association between chemokine expression and clinicopathological factors in gastrointestinal cancer, moreover we investigated how host immune function affect for micro lymph node metastases using mouse model. We showed the expression of CD166 and CD168 in gastric cancer positively correlated with clinical factors and was selected as prognostic marker in gastric cancer for the first time. We could establish micro lymph node metastases model using GFP transfected B17F1 and C57BL.

我们试图阐明胃肠道癌中趋化因子表达和临床病理因素之间的关联，此外，我们研究了使用小鼠模型对微淋巴结转移的宿主免疫功能如何影响。我们在胃癌中显示了CD166和CD168的表达与临床因素正相关，并首次被选为胃癌的预后标记。我们可以使用GFP转染的B17F1和C57BL建立微淋巴结转移模型。

项目成果

StageIV進行胃癌に対する化療後のRO手術の有用性

化疗后 RO 手术对 IV 期晚期胃癌的作用

• 发表时间: 2010
• 作者: Inafuku Y;Furuhata T;Tayama M;Okita K;Nishidate T;Mizuguchi T;Kimura Y;Hirata K;石神純也
• 通讯作者: 石神純也

Safety and efficacy of early postoperative hyperbaric oxygen therapy with restriction of transfusions in patients with HCC who have undergone partial hepatectomy

接受部分肝切除术的 HCC 患者术后早期限制输血高压氧治疗的安全性和有效性

• 发表时间: 2011
• 期刊: Langenbecks Arch Surg
• 作者: Ueno S;Sakoda M;Kurahara H;Iino S;Minami K;Ando K;Mataki Y;Maemura K;Ishigami S;Shinchi H;Natsugoe S.
• 通讯作者: Natsugoe S.

Immediate breast reconstruction using autologous free dermal fat grafts provides better cosmetic results for patients with upper inner cancerous lesions

• DOI: 10.1007/s00595-010-4307-z
• 发表时间: 2011-04-01
• 期刊: SURGERY TODAY
• 影响因子: 2.5
• 作者: Kijima, Yuko;Yoshinaka, Heiji;Natsugoe, Shoji
• 通讯作者: Natsugoe, Shoji

Increased Slug and decreased E-cadherin expression is related to poor prognosis in patients with gastric cancer

• DOI: 10.1007/s10120-011-0004-x
• 发表时间: 2011-03-01
• 期刊: GASTRIC CANCER
• 影响因子: 7.4
• 作者: Uchikado, Yasuto;Okumura, Hiroshi;Natsugoe, Shoji
• 通讯作者: Natsugoe, Shoji

Prognostic value of CD208-positive cell infiltration in gastric cancer

• DOI: 10.1007/s00262-009-0758-8
• 发表时间: 2010-03-01
• 期刊: CANCER IMMUNOLOGY IMMUNOTHERAPY
• 影响因子: 5.8
• 作者: Ishigami, Sumiya;Ueno, Shinichi;Natsugoe, Shoji
• 通讯作者: Natsugoe, Shoji