Development of novel production method of high purity lutetium-177 for advanced cancer therapy

开发用于晚期癌症治疗的高纯度镥177的新型生产方法

• 批准号: 21591586
• 负责人: WATANABE Satoshi
• 金额: $ 2.91万
• 依托单位: Japan Atomic Energy Agency
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591586/
• 关键词: ルテチウム-177; 分離精製法; イミノ二酢酸キレート樹脂; Lu-177; 分離・精製法; 高純度; ルテチム-177

Lutetium-177 is considered to have potential for application in radionuclide therapy, because it emits b-particles suitable to penetrate small tumors. In addition, real time imaging of biodistribution can be done by using the ^<177>Lu, because the energy of g-rays emitted from ^<177>Lu is particularly suitable for imaging by single photon emission computed tomography. In the field of radioimmunotherapy using labeled monoclonal antibodies, to enhance the effect of therapy, no-carrier-added ^<177>Lu produced in the ^<176>Yb(n, g) ^<177>Yb → ^<177>Lu process are desired. In this production, separation of ^<177>Lu from Yb target is required. Therefore, in the present paper, basic study of separation between Lu and Yb by using iminodiacetic acid chelating resin is investigated. It was found that the best separation between Lu and Yb was achieved by using 0.013 M HNO_3 for the eluent and the column of 4.6 mmφｘ450 mm size.

镥177被认为具有在放射性核素治疗中的应用潜力，因为它发射适合穿透小肿瘤的b粒子。此外，由于^<177>Lu的能量，可以进行生物分布的实时成像。从 177 Lu发射的g射线特别适合在使用标记的单克隆抗体的放射免疫治疗领域中通过单光子发射计算机断层扫描来成像。 ^<176>Yb(n，g)^<177>Yb→^<177>Lu过程中产生的无载体添加的^<177>Lu在该生产中期望分离^<。 177>Lu是Yb靶材中必需的，因此，本文对使用亚氨基二乙酸螯合树脂分离Lu和Yb进行了基础研究，发现了两者之间的最佳分离。 Lu和Yb是通过使用0.013M HNO_3作为洗脱液和4.6mmφx450mm尺寸的柱来获得的。

项目成果

Production of Lu-177 capable of labeling antibodies.

生产能够标记抗体的 Lu-177。

• 发表时间: 2009
• 期刊: JAEA-Review
• 作者: Sa. Watanabe;K. Hashimoto;Sh. Watanabe;Y. Iida;H. Hanaoka;K. Endo and N. S. Ishioka
• 通讯作者: K. Endo and N. S. Ishioka