Functional and morphological integrated assessments of hepato-biliary-pancreatic carcinomas using 320 detector-row CT

使用 320 排 CT 对肝胆胰癌进行功能和形态学综合评估

• 批准号: 21591563
• 负责人: YOSHIKAWA Takeshi
• 金额: $ 3.24万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591563/
• 关键词: 領域検出器型CT; 上腹部; 臓器血流・機能測定; 臓器血流測定ソフトウエア; 低X線量CT撮影; 形態・機能融合診断法

We evaluated newly-developed Area-Detector CT in functional and morphological assessments of the upper abdominal organ function and diseases. Area-Detector CT was superior to conventional CT in assessment of fine abdominal vessels. We developed CT scanning protocol and injection protocol of contrast medium for abdominal functional(perfusion) CT, correction software for respiratory misregistrations, and software for perfusion analysis with three different analytic methods. Our results showed irradiation during perfusion CT can be reduced to 1/3 and volume and injection rate of contrast medium can be reduced to 1/3 of those in the conventional methods and respiratory misregistrations less than 3 cm can be satisfactorily corrected. Effects of cardiac function were found and it needs to be compensated. In patients with abdominal diseases, we found new findings such as interactions in blood perfusion among the organs and useful perfusion parameters for diagnosis for malignant tumors. It was also found that perfusion CT is useful for assessment of tumor responses after radiotherapy and anticancer agents as well as residual organ function. The results of this study suggest functional and morphological integrated CT using Area-Detector CT can be superior to those of conventional morphological CT in assessments of the upper abdominal organ function and diseases.

我们在上腹部器官功能和疾病的功能和形态评估中评估了新开发的区域检测器CT。在评估细腹部血管时，区域检测器CT优于常规CT。我们开发了用于腹部功能（灌注）CT的对比介质的CT扫描方案和注射方案，用于呼吸错误的校正软件以及使用三种不同的分析方法进行灌注分析的软件。我们的结果表明，灌注过程中的辐射可以减少至1/3，并且可以将造影剂的体积和注射速率降低到常规方法中的1/3，并且可以满足地校正小于3 cm的呼吸错误注册。发现心脏功能的影响，需要补偿。在腹部疾病的患者中，我们发现了新的发现，例如器官血液灌注中的相互作用，以及用于诊断恶性肿瘤的有用灌注参数。还发现，灌注CT可用于评估放射疗法和抗癌剂以及残留器官功能后的肿瘤反应。这项研究的结果表明，在评估上腹部器官功能和疾病时，使用面积检测器CT的功能和形态综合CT可以优于常规形态CT的功能和形态综合。

项目成果

上腹部CT perfusion :造影剤濃度が解析法に及ぼす影響の検討

上腹部CT灌注：检查造影剂浓度对分析方法的影响

• 发表时间: 2012
• 作者: 神田知紀;吉川武;大野良治;藤澤恭子;金田直樹;小西稔;神山久信;北島一宏;竹中大祐;杉村和朗
• 通讯作者: 杉村和朗

Whole Upper Abdominal CT Perfusion Measurements : Effects of Contrast Medium Iodine Concentration on the Values Estimated by Three Analytic Methods

全上腹部 CT 灌注测量：造影剂碘浓度对三种分析方法估计值的影响

• 发表时间: 2011
• 作者: Kanda T;Yoshikawa T;Ohno Y;Fujisawa Y;Murakami T;Koyama S;Kanata N;Takenaka D;Koyama H;Kitajima K;Sugimura K
• 通讯作者: Sugimura K

Capability of abdominal 320-detector row CT for small vasculature assessment compared with that of 64-detector row CT

腹部 320 排 CT 与 64 排 CT 评估小血管系统的能力比较

• 发表时间: 2011
• 期刊: Eur J Radiol
• 影响因子: 3.3
• 作者: Kitajima K;Maeda T;Ohno Y;Yoshikawa T;Konishi M;Kanda T;Onishi Y;Matsumoto K;Koyama H;Takenaka D;Sugimura K
• 通讯作者: Sugimura K

C Whole Upper Abdominal CT Perfusion Measurements : Optimization of Contrast Medium Administration with 320-Detector Row CT

C 整个上腹部 CT 灌注测量：使用 320 探测器排 CT 优化造影剂给药

• 发表时间: 2010
• 作者: Kanata N;Yoshikawa T;Konishi M;Ohno Y;Kanda T;Koyama H;Takenaka D;Onishi Y;Kitajima K;Koto N;Sugimura K
• 通讯作者: Sugimura K

Optimization of Contrast Medium Administration in Whole Upper Abdominal CT Perfusion Measurements with 320-Detector Row CT

320 排 CT 整个上腹部 CT 灌注测量中造影剂给药的优化

• 发表时间: 2011
• 作者: Yoshikawa T;Kanda T;Ohno Y;Konishi M;Kanata N;Koyama H;Takenaka D;Kitajima K;Sugimura K
• 通讯作者: Sugimura K