Genetic epidemiological study on metabolic syndrome and its application to personalized health promotion

代谢综合征遗传流行病学研究及其在个体化健康促进中的应用

• 批准号: 21590658
• 负责人: TAKESHITA Tatsuya
• 金额: $ 3万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590658/
• 关键词: 肥満; メタボリックシンドローム; アディポネクチン; コーヒー; 内臓脂肪; 生活習慣; 遺伝子多型; アルデヒド脱水素酵素; アルコール; 遺伝疫学; 予防

The association of coffee consumption and MetS-related biomarkers including visceral and subcutaneous fat area(VFA and SFA), total, low-, medium-and high-molecularweight serum adiponectin(T-, LMW-, MMW-and HMW-Ad)levels were analyzed among a total of 364 Japanese male workers(36-61 y old)adjusting for age, alcohol drinking, smoking, walking status and BMI. Both light(1-3 cups/day)and moderate (〓4cups/day)coffee consumption showed significant inverse associations with VFA and VFAISFA ratio(P<0.0001). Moderate coffee consumption showed a favorable tendency toward these associations with T-Ad(P=0.06)and HMW-Ad(P=0.07)levels.The relationship between coffee consumption and the prevalence of metabolic syndrome was investigated in Japanese civil servants. The study participants were 3284 employees(2335 men and 948 women)aged 20 to 65 years. Metabolic syndrome was diagnosed in 3740f the 2335 men(16.0%)and 320f the 948 women(3.4%). In multiple logistic regression analyses, the odds ratios(ORs)among men fbr the presence of metabolic syndrome were 0.61(0.39-0.95), among moderate(〓4 cups of coffee per day)coffee drinkers as compared with non-coffee drinkers. Among all components of metabolic syndrome, high blood pressure and high triglyceride level were inversely associated with moderate coffee consumption in men, after adjusting for age, body mass index, smoking status, drinking status, and exercise. However, in women, moderate coffee consumption was not significantly associated with the prevalence of metabolic syndrome or its components.

The association of coffee consumption and MetS-related biomarkers including visceral and subcutaneous fat area (VFA and SFA), total, low-, medium-and high-molecularweight serum adiponectin(T-, LMW-, MMW- and HMW-Ad) levels were analyzed among a total of 364 Japanese male workers(36-61 y old)adjusting for age, alcohol drinking, smoking, walking status and BMI。光（每天1-3杯）和中等（4杯/天）的咖啡消费均与VFA和VFAISFA比率显着相关（p <0.0001）。MimentaliveCoffee消费均表现出与T-AD相关的有利趋势，与T-AD（P = 0.06）和HMW-AD（p = 0.07）级别的综合综合均具有相关性。公务员。研究参与者是20至65岁的3284名员工（2335名男性和948名妇女）。在3740F的2335名男性（16.0％）和320F 948名妇女（3.4％）中诊断出代谢综合征。在多种逻辑回归分析中，与非咖啡者相比，在中度（每天4杯咖啡咖啡）中，代谢综合征的存在比值比（ORS）为0.61（0.39-0.95）。在适应年龄，体重指数，吸烟状况，饮酒状态和运动后，在代谢综合征的所有组成部分中，高血压和高甘油三酸酯水平与中等咖啡的消费成反比。但是，在女性中，中等咖啡的消费与代谢综合征或其成分的患病率没有显着相关。

项目成果

肥満関連遺伝子多型とメタボリックシンドロームの関連性

肥胖相关基因多态性与代谢综合征的关系

• 发表时间: 2011
• 作者: 山野優子;立道昌幸;宮川三平;中館俊夫;牟礼佳苗,竹下達也,前田真也,麦谷耕一,岩根幹能,木下藤寿,茂原 治
• 通讯作者: 牟礼佳苗,竹下達也,前田真也,麦谷耕一,岩根幹能,木下藤寿,茂原 治

Association of monocyte subset counts with coronary fibrous cap thickness in patients with unstable angina pectoris

• DOI: 10.1016/j.atherosclerosis.2010.06.025
• 发表时间: 2010-10-01
• 期刊: ATHEROSCLEROSIS
• 影响因子: 5.3
• 作者: Imanishi, Toshio;Ikejima, Hideyuki;Akasaka, Takashi
• 通讯作者: Akasaka, Takashi

コーヒー摂取等の生活習慣とメタボリックシンドロームとの関連性について

关于咖啡摄入量等生活习惯与代谢综合征的关系

• 发表时间: 2011
• 作者: 牟礼 佳苗;前田真也;麦谷耕一;岩根幹能;木下藤寿;茂原治;竹下達也
• 通讯作者: 竹下達也

Eradication of Helicobacter pylori prevents cancer development in subjects with mild gastric atrophy identified by serum pepsinogen levels

• DOI: 10.1002/ijc.24591
• 发表时间: 2009-12-01
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Yanaoka, Kimihiko;Oka, Masashi;Ichinose, Masao
• 通讯作者: Ichinose, Masao

Inverse association of habitual coffee consumption with metabolic syndrome-related biomarkers involving adiponectin

习惯性喝咖啡与涉及脂联素的代谢综合征相关生物标志物呈负相关

• 发表时间: 2013
• 期刊: Nutrition
• 影响因子: 4.4
• 作者: Mure K;Maeda S;Mukoubayashi C;Mugitani K;Iwane M;Kinoshita F;Mohara O and Takeshita T
• 通讯作者: Mohara O and Takeshita T