Fundamental Study for New Crystal Capsule Formed by Using Nucleation of mutual anti-solvent crystallization

互反溶剂结晶成核形成新型晶囊的基础研究

• 批准号: 21560782
• 负责人: MAEDA Kouji
• 金额: $ 3万
• 依托单位: University of Hyogo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21560782/
• 关键词: 晶析操作; Crystal Capsule; Co-Crystals; Anti-Solvent; Co-Solvent; Molecular Dynamics; Nuclei; Spray Dry; Crystal capsule; Co-crystals; Anti-solvent; Co-solvent; Molecular dynamics; Cluster; Spray dry; cluster; Splay dry

Mixed crystals of crystal capsule structure have been formed by mutual anti-solvent crystallization. One solution is sprayed onto the bulk solution. The mixed crystals were made of aqueous solute (ammonium chloride or glycine) and fatty acid. The structure of the crystals was analyzed by XRD, and it was found that the mixed crystals have two individual crystal patterns of the composed substances. Macroscopic structure was the capsule of aqueous solute crystal surrounded by fatty acid crystals. The long-range structure was also analyzed by SAX of Spring-8, and it was found that the crystal structure of fatty acid was slightly shifted to large structure with ammonium chloride inclusions. The deformation of those capsules was effectively performed by the addition of solvent.

通过互反溶剂结晶形成晶囊结构的混合晶体。将一种溶液喷涂到本体溶液上。混合晶体由水溶质（氯化铵或甘氨酸）和脂肪酸制成。通过XRD分析晶体的结构，发现混合晶体具有两种单独的组成物质的晶型。宏观结构为被脂肪酸晶体包围的水溶质晶体的胶囊。 Spring-8的SAX也对长程结构进行了分析，发现脂肪酸的晶体结构稍微向大结构移动，并带有氯化铵夹杂物。通过添加溶剂可以有效地实现这些胶囊的变形。

项目成果

水溶性各種リン酸塩の溶解特性とその応用

各种水溶性磷酸盐的溶解特性及其应用

• 发表时间: 2012
• 期刊: Bull. Soc. Sea Water Sci. Jpn.
• 作者: 前田光治;飯村健次;倉持秀敏;福井啓介
• 通讯作者: 福井啓介

New Mutual Antisolvent Crystallization Method for Organic and Inorganic Substances

有机和无机物质互抗溶剂结晶新方法

• 发表时间: 2011
• 作者: N. Arakawa;K. Maeda;K. Fukui
• 通讯作者: K. Fukui

Nucleation of Ammonium Salts in Aqueous Solution by High Pressure

• DOI: 10.1088/1742-6596/215/1/012066
• 发表时间: 2010-01-01
• 期刊: INTERNATIONAL CONFERENCE ON HIGH PRESSURE SCIENCE AND TECHNOLOGY, JOINT AIRAPT-22 AND HPCJ-50
• 作者: Maeda, K.;Asakuma, Y.;Fukui, K.
• 通讯作者: Fukui, K.

Molecular Dynamics of Crystallization Processes

结晶过程的分子动力学

• 发表时间: 2012
• 作者: K. Maeda;K. Fukui
• 通讯作者: K. Fukui

De-emulsification of mixtures containing glycerin and fatty acid methyl ester promoted by dimethyl ether co-solvent

二甲醚助溶剂促进甘油和脂肪酸甲酯混合物的破乳

• 发表时间: 2011
• 期刊: Chem. Eng. J
• 作者: K. Maeda;H. Kuramochi;Y. Asakuma;K. Fukui;T. Tsuji;M. Osako;S. Sakai
• 通讯作者: S. Sakai