Inner ear fluid metabolism regulated by natriuretic peptide family

利尿钠肽家族调节内耳液体代谢

• 批准号: 20591991
• 负责人: SUZUKI Mikio
• 金额: $ 3万
• 依托单位: University of the Ryukyus
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591991/
• 关键词: ナトリウム利尿ペプチド; メニエール病; 内リンパ嚢; 内リンパ水腫; ANP; BNP; CNP; 内リンパ液; 外リンパ液; ナトリウム利尿ペプチド; メニエール病; 内リンパ嚢; 内リンパ水腫; ANP; BNP; CNP; 内リンパ液; 外リンパ液

In the present study, natriuretic peptide receptors were observed in spiral ligament and epithelium of endolymphatic sac. Although audiological function and inner ear structure in the guinea pigs with endolymphatic hydrops were not affected by natriuretic peptide infusions to both inner ear and peritoneal cavity, CNP knockout mice displayed significant hearing loss, comparing with controls. ANP receptors were observed in human endolymphatic sac as well as rat endolymphatic sac, and the levels of serum BNP in patients with endolymphatic hydrops were significantly elevated. These observations suggest that natriuretic peptides may be involved in inner ear fluid metabolism. The further studies are needed to confirm the observations.

在本研究中，在内淋巴囊的螺旋韧带和上皮中观察到亚钠肽受体。尽管带有内淋巴水滴的豚鼠中的听觉功能和内耳结构并未受到内耳和腹膜腔输注的纳地酸肽输注的影响，但与对照相比，CNP敲除小鼠表现出明显的听力损失。在人内膜囊和大鼠内淋巴囊中观察到ANP受体，并且内淋巴水流患者的血清BNP水平显着升高。这些观察结果表明，亚钠肽可能参与内耳液代谢。需要进一步的研究来确认观察结果。