Study for interaction between D-serine synthesis and development of morphine tolerance

D-丝氨酸合成与吗啡耐受性发展之间相互作用的研究

• 批准号: 20591843
• 负责人: ITO Kenji
• 金额: $ 3.08万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591843/
• 关键词: 疼痛管理学; モルヒネ; 麻薬; ケタミン; Dセリン; セリンラセマーゼ; Dアミノ酸酸化酵素; 鎮痛; 耐性; in situ hybridization; 免疫組織化学; NMDA受容体

Repeated administration of morphine for 30 days produced a significant augmentations of both the mRNA and protein expressions of serine racemase in all the brain regions, and caused a slight but significant elevation in the elevated D-seirne revel in the cortex, striatum and hippocampus. The antinociception induced by the intracerebroventricular (i.c.v.) administration of D-serine was attenuated by i.c.v. administration of midazolam. These results indicate the elevated D-serine level following the chronic morphine treatment could at least in part be involved in the activation of NMDA receptors via the glycine site.

重复给予吗啡30天，在所有大脑区域中，丝氨酸种族酶的mRNA和蛋白质表达都显着增强，并导致升高的D-Seirne Revel在皮质，纹状体和海马的D-Seirne Revel升高但显着升高。 I.C.V.抑制了脑室内（I.C.V.）给药诱导的抗伤害感受。咪达唑仑的管理。这些结果表明，慢性吗啡处理后的D丝氨酸水平升高至少可以部分参与通过甘氨酸部位激活NMDA受体。

项目成果

Midazolam attenuates the antinociception induced by D-serine or morphine at the supraspinal level in rats

• DOI: 10.1016/j.ejphar.2008.02.068
• 发表时间: 2008-05-31
• 期刊: EUROPEAN JOURNAL OF PHARMACOLOGY
• 影响因子: 5
• 作者: Ito, Kenji;Yoshikawa, Masanobu;Hashimoto, Atsushi
• 通讯作者: Hashimoto, Atsushi

Inhibitory effect of low-dose pentazocine on the development of antinociceptive tolerance to morphine

• DOI: 10.1007/s00540-008-0697-0
• 发表时间: 2009-02-01
• 期刊: JOURNAL OF ANESTHESIA
• 影响因子: 2.8
• 作者: Chiba, Shunsuke;Hayashida, Masakazu;Yamada, Yoshitsugu
• 通讯作者: Yamada, Yoshitsugu

Long-Torm Treatmont With Morphino Increases tho D-Seine Content in the Rat Brain by Regulating the mRNA and Protein Expressions of Serine Racemase and D-Amino Acid Oxidase

吗啡长效治疗通过调节丝氨酸消旋酶和 D-氨基酸氧化酶的 mRNA 和蛋白质表达来增加大鼠大脑中的 D-丝氨酸含量

• 发表时间: 2008
• 期刊: Journal of Pharmacological Sciences 107
• 作者: 樫葉均;仙波恵美子;Masanobu Yoshikawa
• 通讯作者: Masanobu Yoshikawa

The serine racemase mRNA is expressed in both neurons and glial cells of rat retina

丝氨酸消旋酶 mRNA 在大鼠视网膜神经元和神经胶质细胞中表达

• 发表时间: 2008
• 期刊: Arch Histol Cytol 71(2)
• 作者: Takayasu N;Yoshikawa M;Watanabe M;Tsukamoto H;Suzuki T;Kobayashi H;Noda S
• 通讯作者: Noda S

Chronic administration of methamphetamine increases the mRNA expression of diazepam binding inhibitor in rat brain

长期服用甲基苯丙胺会增加大鼠脑中地西泮结合抑制剂的 mRNA 表达

• 发表时间: 2008
• 期刊: Tokai J Exp Clin Med 33(1)
• 作者: Tamaki R;Yoshikawa M;Shinomiya T;Andoh H;Kawaguchi M;Hashimoto A;Bryne WD;Kobayashi H.
• 通讯作者: Kobayashi H.