Microarray analysis of carotid plaques on the basis of Agatston scores
基于 Agatston 评分的颈动脉斑块微阵列分析
基本信息
- 批准号:20591692
- 负责人:
- 金额:$ 2.91万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2008
- 资助国家:日本
- 起止时间:2008 至 2010
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We reconstructed MDCT images of the patients of carotid stenoses and calculated Agatston scores (AS). Gene tip expression array analysis was performed after extraction of mRNAs from carotid plaques. Over double difference was noted for the intensity of the expression for inflammation-related genes after comparison of specimens classified based on AS100. Upregulation of NFAT, ADAMTS, Angptl4 and downregulation of Angptl7 were observed in severely calcified plaques.
我们重建了颈动脉狭窄患者的MDCT图像,并计算出Agatston评分(AS)。从颈动脉斑块中提取mRNA后,进行了基因尖端表达阵列分析。在比较基于AS100的标本后,与炎症相关基因的表达强度的强度值得注意。在严重钙化的斑块中观察到了NFAT,ADAMT,ANGPTL4和ANGPTL7下调的上调。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Hypoxia-inducible factor-1 alpha and vascular endothelial growth factor in the carotid atheroma are expressed more in symptomatic cases than in asymptomatic cases.
颈动脉粥样斑块中缺氧诱导因子 1 α 和血管内皮生长因子在有症状病例中的表达量高于无症状病例。
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:Osawa T;Mase M;Tanikawa M;Fujita M;Katano H;Aoyama K;Ohno T;Sakurai K;Sasaki S;Yamada K
- 通讯作者:Yamada K
The twisted carotid bifurcation and microthrombendarterectomy.
扭转颈动脉分叉和微血栓切除术。
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:片野広之;山田和雄
- 通讯作者:山田和雄
GOS, ADLからみた頚動脈狭窄症ハイリスク症例
从GOS和ADL角度看颈动脉狭窄高危病例
- DOI:
- 发表时间:2008
- 期刊:
- 影响因子:0
- 作者:片野広之;南光徳偉;日向崇教;大蔵篤彦;岡雄一;間瀬光人;山田和雄
- 通讯作者:山田和雄
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KATANO Hiroyuki其他文献
KATANO Hiroyuki的其他文献
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{{ truncateString('KATANO Hiroyuki', 18)}}的其他基金
Investigation of stability of calcified plaque by miRNA profiling
通过 miRNA 分析研究钙化斑块的稳定性
- 批准号:
26462169 - 财政年份:2014
- 资助金额:
$ 2.91万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
calcified carotid plaque and inflammation/calcification-related genes
颈动脉钙化斑块和炎症/钙化相关基因
- 批准号:
23592102 - 财政年份:2011
- 资助金额:
$ 2.91万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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- 批准号:
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