Study on roles of neurogenesis and peripheral blood BDNF in depression.

神经发生和外周血BDNF在抑郁症中的作用研究。

• 批准号: 20591373
• 负责人: HASHIMOTO Eri
• 金额: $ 2.91万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591373/
• 关键词: 神経科学; 脳・神経; うつ病; 神経新生; BDNF; 抗うつ薬; 血小板; 末梢血; 神経科学; 脳・神経; うつ病; 神経新生; BDNF; 抗うつ薬; 血小板; 末梢血

We analyzed the influence of antidepressants on platelet BDNF release in rats. BDNF was dose-dependently released from platelets by direct treatment with various kinds of antidepressants in vitro. Sertraline-induced BDNF release from platelets was reduced in the presence of TrkB inhibitor, K252a in a rat model of depression compared with control rats. We also investigated neuroserpin expression in adult rat SGZ and found that neuroserpin may play some roles in early stage of neurogenesis in adult rat hippocampus.

我们分析了抗抑郁药对大鼠血小板BDNF释放的影响。通过在体外用各种抗抑郁药直接处理，BDNF剂量依赖于血小板。与对照大鼠相比，在TRKB抑制剂的存在下，在TRKB抑制剂的存在下，在TRKB抑制剂（K252a）的存在下降低了血小板的BDNF释放。我们还研究了成年大鼠SGZ中的神经蛋白表达，发现神经毒素可能在成年大鼠海马的神经发生早期起作用。