Combined <11>^C-Choline PET with high-resolution MRI : Development for T- and N-Stage Assessment in Patients with Prostate Cancer.

11C-胆碱 PET 与高分辨率 MRI 相结合：前列腺癌患者 T 期和 N 期评估的开发。

基本信息

批准号：
20790897
负责人：
MAEDA Tetsuo
金额：
$ 2.75万
依托单位：
Kobe University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2008
资助国家：
日本
起止时间：
2008 至 2009
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790897/
关键词：
前立腺がんコリンPET MRI

项目摘要

We evaluated the preliminary result of combined <11>^C-choline PET and CT or MRI for T- and N-stage assessments in candidates for radical prostatectomy due to biopsy-proven prostatic cancer. Thirty-four pathologically diagnosed prostate cancer patients prospectively underwent <11>^C-choline PET, unenhanced whole-body MDCT and pelvic MRI prior to surgical resection. Then, a board-certified radiologist and a nuclear medicine physician assessed T- and N-stage in each patient on combined PET with CT or MRI (combined PET-CT/MRI), and final diagnosis in each patient was made by consensus of two readers. When all images were evaluated, readers were unaware of any clinical information and histological results. Then, assessed T- and N-stage in each patient were compared with each T- and N-stages based on pathological results, and diagnostic tendency were determined. Thirty-two cases underwent radical prostatectomies, and two cases were underwent exploratory laparotomies due to a detection of pelvic lymph nodes metastases. Postoperative T staging were pT2b (n=13), pT3a (n=8), pT3b (n=1), and pT4 (n=10). On T-stage assessment, combined PET-CT/MRI could correctly diagnose in all patients with pT2b and pT3a, whereas this method could not correctly diagnose in patients with pT3b and pT4. On N-stage assessment, all lymph node metastases, whose short axis diameters were more than 7mm, were correctly diagnosed on combined PET-CT/MRI. Our preliminary result suggests that combined PET-CT/MRI might be useful for T- and N-stage assessments in patients with prostatic cancer. We presented the result on 12^<th> Asian Oceanian Congress of Radiology. Further studies are needed to clarify the usefulness of this method.

我们评估了组合<11>^C-胆碱PET和CT或MRI的初步结果，以进行T阶段和N阶段评估，该候选因活检预处理前列腺癌而导致的根治性前列腺切除术。在手术切除之前，有34例病理诊断的前列腺癌患者前瞻性接受<11>^C-胆碱PET，未增强的全身MDCT和骨盆MRI。然后，由董事会认证的放射科医生和核医学医师评估了每位患者与CT或MRI合并的患者的T和N阶段（PET-CT/MRI联合使用），并通过两种共识进行了每位患者的最终诊断读者。评估所有图像时，读者不知道任何临床信息和组织学结果。然后，根据病理结果将每个患者的T和N阶段评估的T级和N阶段进行比较，并确定诊断趋势。由于发现骨盆淋巴结转移酶的检测，有32例接受了根治性前列腺切除术，两例接受了探索性腹腔。术后t分期为PT2B（n = 13），PT3A（n = 8），PT3B（n = 1）和PT4（n = 10）。在T级评估中，PET-CT/MRI合并可以在所有PT2B和PT3A患者中正确诊断，而PT3B和PT4患者无法正确诊断此方法。在N阶段评估中，所有淋巴结转移（其短轴直径大于7mm）均在PET-CT/MRI联合诊断上正确诊断。我们的初步结果表明，PET-CT/MRI组合可能可用于前列腺癌患者的T阶段和N阶段评估。我们在12^<th>亚洲大洋洲放射学大会上提出了结果。需要进一步的研究来阐明该方法的实用性。