The therapeutic mechanisms of action of kakkonto in a mouse model of food allergy with gastrointestinal symptoms.

kakkonto 在具有胃肠道症状的食物过敏小鼠模型中的治疗机制。

• 批准号: 20790472
• 负责人: YAMAMOTO Takeshi
• 金额: $ 2.75万
• 依托单位: University of Toyama (2009)Toyama Medical and Pharmaceutical University (2008)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790472/
• 关键词: 食物アレルギー; 葛根湯; 腸管粘膜免疫; マイクロアレイ; 漢方薬; 腸管粘膜免疫系; サイトカイン; T細胞; 粘膜型マスト細胞; 食物アレルギー; 葛根湯; 腸管粘膜免疫; マイクロアレイ; 漢方薬; 腸管粘膜免疫系; サイトカイン; T細胞; 粘膜型マスト細胞

The number of patients with food allergy has increased dramatically over the last several decades. However, there is no effective drug for food allergies. My results indicate that kakkonto has therapeutic effects on the development of allergic diarrhea in mouse food allergy model. The development of allergic diarrhea resulted from the enhancement of immune responses and the infiltration of mucosal mast cells in the colon. Kakkonto has immunosuppressive effects on the enhanced immune responses and interferes with the infiltration of mucosal mast cells in the colons of food allergy mouse, leading to improvement of allergic symptoms. Moreover, the transcriptome analyses reveal that the effects of kakkonto is due to the regulation of the differentiation and the activation of T cells.

在过去的几十年中，食物过敏的患者数量急剧增加。但是，没有有效的食物过敏的药物。我的结果表明，Kakkonto对小鼠食物过敏模型中过敏性腹泻的发展具有治疗作用。过敏性腹泻的发育是由免疫反应的增强和结肠中粘膜肥大细胞浸润所致。 Kakkonto对增强的免疫反应具有免疫抑制作用，并干扰食物过敏小鼠结肠中粘膜肥大细胞的浸润，从而改善过敏症状。此外，转录组分析表明，Kakkonto的作用是由于T细胞的分化和激活的调节所致。