Evolution of podocyte and primary urine-producing organs

足细胞和初级产尿器官的进化

• 批准号: 20790166
• 负责人: ICHIMURA Koichiro
• 金额: $ 2.5万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790166/
• 关键词: 比較解剖学; 比較細胞組織学; 比較細胞生物学; 腎臓学; 腎臓; 糸球体; 原尿; 足細胞; 細胞骨格; 線毛; 排泄器官; アクチン結合蛋白質; 比較解剖学; 比較細胞組織学; 比較細胞生物学; 腎臓学; 腎臓; 糸球体; 原尿; 足細胞; 細胞骨格; 線毛; 排泄器官; アクチン結合蛋白質

Mammals and birds possess high-performance primary-urine producing apparatus(renal glomerulus) by virtue of their high blood pressure. However, the protection mechanisms of glomerular structure from the high intraglomerular pressure and fluid shear stress remain poorly understood. In this study, we found that primary cilium, which is one of the fluid mechanosensors, disappeared from the glomerular podocytes in mammalian and bird metanephros. The primary cilia on the podocytes are subjected to a stronger bending force in mammals and birds. Thus the disappearance of the primary cilia presumably prevents the entry of excessive calcium-ion via the cilium-associated calcium channels and the disturbance of intracellular signaling cascades in podocytes.

哺乳动物和鸟类由于其高血压而具有高性能的原发性产生设备（肾肾小球）。然而，高磁性内压和液体剪切应力的肾小球结构的保护机制仍然很熟悉。在这项研究中，我们发现原发性纤毛是流体机械传感器之一，从哺乳动物和鸟类倍虫的肾小球足细胞中消失。足细胞上的主要纤毛在哺乳动物和鸟类中受到更强的弯曲力。因此，原发性纤毛的消失可能阻止了通过纤毛相关的钙通道进入过多的钙离子，并且在足细胞中的细胞内信号传导级联反应。