Elucidation of molecular basis of specific action mechanisms of antimicrobial peptides from lactic acid bacteria

阐明乳酸菌抗菌肽特定作用机制的分子基础

• 批准号: 20780055
• 负责人: ZENDO Takeshi
• 金额: $ 2.66万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20780055/
• 关键词: 微生物機能; 乳酸菌; 抗菌ペプチド; バクテリオシン; 微生物機能; 乳酸菌; 抗菌ペプチド; バクテリオシン

The structures of various novel antimicrobial peptides, bacteriocins, from lactic acid bacteria were determined. One of the novel bacteriocins, lactocyclicin Q, is a cyclic peptide whose N- and C-terminals are bound with a peptide bond. Lacticin Q exerts antimicrobial activity via huge pore formation on bacterial cell membrane that causes leakage of cellular components such as ATP and small proteins. Since the actions of lacticin Q and lipids accords with the characteristics of Toroidal Pore model, the action mechanism of lacticin Q was termed Huge Toroidal Pore model .

确定了乳酸菌细菌的各种新型抗菌肽，细菌素的结构。一种新型的细菌素乳肽素Q是一种环状肽，其N-和C末端与肽键结合。乳酸Q通过在细菌细胞膜上形成巨大的毛孔形成抗菌活性，从而导致细胞成分（例如ATP和小蛋白质）泄漏。由于乳酸Q和脂质的作用符合环孔模型的特征，因此乳酸Q的作用机理称为巨大的环形孔模型。