Gene-gene and gene-environment interactions between polymorphisms in alcohol-metabolizing enzyme genes and the risk of gastric cancer

酒精代谢酶基因多态性与胃癌风险之间的基因-基因和基因-环境相互作用

• 批准号: 20590624
• 负责人: HIRAKI Akio
• 金额: $ 3.08万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590624/
• 关键词: 胃がんリスク; 胃がん; 罹患リスク

H.pylori seropositivity in the controls was not significantly associated with the AICDA 7888 C/T genotypes. Among the H. pylori seropositive control subjects, the age and sex-adjusted ORs of atrophic gastritis were not statistically significant. The age- and sex-adjusted ORs of gastric cancer relative to atrophic gastritis were also not statistically significant. The hypothetical association of the AICDA 7888 C/T polymorphism with the risk of gastric cancer or gastric atrophy was not shown in this study.

对照中的幽门螺杆菌血清阳性与 AICDA 7888 C/T 基因型没有显着相关。在幽门螺杆菌血清阳性对照受试者中，萎缩性胃炎的年龄和性别调整 OR 没有统计学意义。胃癌相对于萎缩性胃炎的年龄和性别调整 OR 也没有统计学意义。本研究未显示 AICDA 7888 C/T 多态性与胃癌或胃萎缩风险的假设关联。

项目成果

Interaction of the effects of alcohol drinking and polymorphisms in alcohol-metabolizing enzymes on the risk of female breast cancer in Japan.

• DOI: 10.2188/jea.je20081035
• 发表时间: 2009
• 期刊: Journal of epidemiology
• 影响因子: 4.7
• 作者: Kawase T;Matsuo K;Hiraki A;Suzuki T;Watanabe M;Iwata H;Tanaka H;Tajima K
• 通讯作者: Tajima K

No association between AICDA 7888 C/T polymorphism, Helicobacter pylori seropositivity, and the risk of atrophic gastritis and gastric cancer in Japanese.

日本人的 AICDA 7888 C/T 多态性、幽门螺杆菌血清阳性与萎缩性胃炎和胃癌的风险之间没有关联。

• 发表时间: 2010
• 期刊: Gastric Cancer. 13(1)
• 作者: Hishida A;Matsuo K;Goto Y;Mitsuda Y;Hiraki A;Naito M;Wakai K;Tajima K;Hamajima N.
• 通讯作者: Hamajima N.