Studies on the roles for 8-nitroguanosine 3',5'-cyclic monophosphate in the cardiovascular system and the applications to drug discovery.

8-硝基鸟苷3,5-环单磷酸在心血管系统中的作用及其在药物发现中的应用研究。

• 批准号: 20590255
• 负责人: TOKUTOMI Yoshiko
• 金额: $ 3万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590255/
• 关键词: cGMP; eNOS; 心血管系; NO; 一酸化窒素; db

8-Nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP), formed nitric oxide (NO)-dependently, is a novel physiological second messenger. To study the physiological activity of 8-nitro-cGMP in the cardiovascular system, we studied its effects on vascular reactivity of mouse aortas. 8-Nitro-cGMP induced enhancement of contraction to phenylephrine and relaxation concentration-dependently in aortas from non-diabetic mice, but only relaxation in aortas from diabetic mice. It was suggested that 8-nitrocGMP- induced superoxide production via eNOS uncoupling may mediate the enhancement of the phenylephrine contraction. The vasodilator effect of 8-nitro-cGMP may contribute to amelioration of the vascular endothelial dysfunction in diabetic mice, representing a novel pharmacological approach toprevent the complications associated with diabetes.

8-硝基鸟苷 3',5'-环单磷酸 (8-硝基-cGMP) 依赖一氧化氮 (NO) 形成，是一种新型的生理第二信使。为了研究 8-硝基-cGMP 在心血管系统中的生理活性，我们研究了它对小鼠主动脉血管反应性的影响。 8-硝基-cGMP 诱导非糖尿病小鼠主动脉中去氧肾上腺素的收缩和舒张浓度依赖性增强，但仅导致糖尿病小鼠主动脉舒张。有人提出，8-硝基鸟苷酸通过 eNOS 解偶联诱导超氧化物产生，可能介导去氧肾上腺素收缩的增强。 8-硝基-cGMP 的血管扩张作用可能有助于改善糖尿病小鼠的血管内皮功能障碍，代表了一种预防糖尿病相关并发症的新药理学方法。

项目成果

8-Nitro-cGMPの血管系への作用

8-硝基-cGMP 对血管系统的影响

• 发表时间: 2009
• 作者: 松田直之;服部裕一;児玉亨;徳冨芳子
• 通讯作者: 徳冨芳子

Potentiation by candesartan of protective effects of pioglitazone against type 2 diabetic cardiovascular and renal complications in obese mice

• DOI: 10.1097/hjh.0b013e32833366cd
• 发表时间: 2010-02-01
• 期刊: JOURNAL OF HYPERTENSION
• 影响因子: 4.9
• 作者: Fukuda, Masaya;Nakamura, Taishi;Kim-Mitsuyama, Shokei
• 通讯作者: Kim-Mitsuyama, Shokei

Critical Role of Apoptosis Signal-Regulating Kinase 1 in Aldosterone/Salt-Induced Cardiac Inflammation and Fibrosis

• DOI: 10.1161/hypertensionaha.109.135392
• 发表时间: 2009-09-01
• 期刊: HYPERTENSION
• 影响因子: 8.3
• 作者: Nakamura, Taishi;Kataoka, Keiichiro;Kim-Mitsuyama, Shokei
• 通讯作者: Kim-Mitsuyama, Shokei

Effects of 8-nitro-cGMP on vascular responsiveness.

8-硝基-cGMP 对血管反应性的影响。

• 发表时间: 2009
• 期刊: Journal of Pharmacological Sciences 109(Suppl)
• 作者: Tokutomi Y;et al
• 通讯作者: et al

Aliskiren prevents cardiovascular complications and pancreatic injury in a mouse model of obesity and type 2 diabetes

• DOI: 10.1007/s00125-009-1575-5
• 发表时间: 2010-01-01
• 期刊: DIABETOLOGIA
• 影响因子: 8.2
• 作者: Dong, Y. F.;Liu, L.;Kim-Mitsuyama, S.
• 通讯作者: Kim-Mitsuyama, S.