Notochord-Neuron interaction during the chordate evolution.

脊索动物进化过程中脊索-神经元的相互作用。

• 批准号: 20570214
• 负责人: TAKAHASHI Hiroki
• 金额: $ 3.16万
• 依托单位: National Institute for Basic Biology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20570214/
• 关键词: 脊索; 神経; 発生; 進化; ホヤ

The midline organ notochord and its overlying dorsal neural tube are the most prominent features of the chordate body plan. Although molecular mechanisms involved in the dorsal patterning of the nervous system have been studied extensively in vertebrate embryos, none of the genes that are expressed specifically in notochord cells have been shown to function in this process. Here, we report a gene in the urochordate Ciona intestinalis encoding a fibrinogen-like protein that plays a pivotal role in the notochord-dependent dorsal positioning of neuronal cells. Therefore, it is highly likely that the interaction of the notochord-based fibrinogen-like protein and the neural tube-based Notch signaling is essential for the dorsal patterning of the nervous system or for the establishment of the chordate body plan.

中线器官脊索及其上覆的背神经管是Chordate身体计划中最突出的特征。尽管已经在脊椎动物胚胎中广泛研究了与神经系统背面形式相关的分子机制，但在脊椎动物细胞中没有明确表达的基因在此过程中发挥作用。在这里，我们报告了编码类似纤维蛋白原的蛋白的Urochordate ciona intestinalis中的基因，该蛋白在神经元细胞的脊索依赖性背定位中起关键作用。因此，很有可能基于脊索纤维蛋白原样蛋白和基于神经管的凹口信号的相互作用对于神经系统的背模式或建立Chordate体计划至关重要。

项目成果

Ciona intestinalis Noto4 contains a phosphotyrosine interaction domain and is involved in the midline intercalation of notochord cells

海鞘 Noto4 含有磷酸酪氨酸相互作用结构域，参与脊索细胞的中线嵌入

• 发表时间: 2010
• 期刊: Int.J.Dev.Biol. (in press)
• 作者: Yamada;S.;Ueno;N.;Satoh;N.;Takahashi;H.
• 通讯作者: H.

Brachyury-downstream gene sets in a chordate, Ciona intestinalis:: integrating notochord specification, morphogenesis and chordate evolution

• DOI: 10.1111/j.1525-142x.2007.00212.x
• 发表时间: 2008-01-01
• 期刊: EVOLUTION & DEVELOPMENT
• 影响因子: 2.9
• 作者: Hotta, Kohji;Takahashi, Hiroki;Gojobori, Takashi
• 通讯作者: Gojobori, Takashi

Novel peripheral neuron network in the tunic of normal ascidian revealed by confocal laser scanning and transmission electron microscopies.

通过共焦激光扫描和透射电子显微镜揭示正常海鞘外衣中的新型周围神经元网络。

• 发表时间: 2010
• 期刊: Dev.Dynamics. 239
• 作者: Terakubo H.;Nakajima Y.;Sasakura Y.;Horie T.;Konno A.;Takahashi H.;Inaba K.;Hotta K.;Oka K.
• 通讯作者: Oka K.

Interaction of notochord-derived fibrinogen-like protein with Notch reg ulates the patterning of the central nervous system of Ciona intestinalis embryos

脊索来源的纤维蛋白原样蛋白与 Notch 的相互作用调节玻璃海鞘胚胎中枢神经系统的模式

• 发表时间: 2009
• 期刊: Dev. Biol. 328
• 作者: Yamada;S.;Hotta;K.;Yamamoto;T. S.;Ueno;N.;Satoh;N.;Takahashi;H.
• 通讯作者: H.

Ciona intestinalis Noto4 contains a phosphotyrosine interaction domain and is involved in the midline intercalation of notochord cells.

海鞘 Noto4 含有磷酸酪氨酸相互作用结构域，参与脊索细胞的中线嵌入。

• 发表时间: 2011
• 期刊: Int.J.Dev.Biol. 55
• 作者: Yamada S.;Ueno N.;Satoh N.;Takahashi H.
• 通讯作者: Takahashi H.