Translational research for establishment of heavy ion radiotherapy for cancer

建立癌症重离子放射治疗的转化研究

• 批准号: 20390324
• 负责人: NAKANO Takashi
• 金额: $ 11.9万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390324/
• 关键词: 重粒子線; 放射線治療; 放射線生物学; 粒子線治療; 放射線腫瘍学; 重粒子線; 放射線治療; 放射線生物学; 粒子線治療; 放射線腫瘍学

1) Carbon-ion beams were about 10-fold more effective than X-rays in immature hippocampal neurons. X-irradiation immediately induced morphological changes in axons and dendrite. These changes seemed to be caused by x-irradiation evoking depolymerization of microfilament. 2) Under severe hypoxic condition for 1 hour, oxygen enhancement ratio (OER) of X-ray was calculated as 2.7. Under severe hypoxic condition for 24 hour, OER of X-ray was decreased from 2.6 to 1.1 by addition of mTOR inhibitor but, OER was not changed in carbon-ion beam irradiation. 3) The RBE of C-beams to X-rays in the normal cerebellum of infant rats with rat organotypic slice culture system was assumed to be 1.4.4) Radiation-induced ICAM-1 expression on HUVE cells was regulated by TGF-β1 and carbon-beam induced higher ICAM-1 expression than X-ray. 5) HIF-1α expression was a prognostic factor in patients with locally advanced rectal cancer. 6) The cost-effectiveness of carbon beam therapy was good for advanced rectal cancers and lung cancers by analyzing clinical data.

1）在未成熟的海马神经元中，碳离子束比X射线高约10倍。 X辐射立即诱导轴突和树突的形态变化。这些变化似乎是由X辐射引起的微丝沉积引起的。 2）在严重的低氧条件下1小时，X射线的氧增强比（OER）计算为2.7。在严重的低氧条件下24小时，X射线的OER通过添加MTOR抑制剂从2.6降低至1.1，但在碳 - 离子束照射中没有改变OER。 3）在婴儿大鼠的正常小脑中，用大鼠有机切片培养系统的X射线向X射线X射线为1.4.4）辐射诱导的HUVE细胞上的ICAM-1表达受TGF-β1和碳链诱导的ICAM-1表达高于X射线。 5）HIF-1α表达是局部晚期直肠癌患者的预后因素。 6）通过分析的临床数据，碳梁治疗的成本效益对晚期直肠癌和肺癌有益。