Does the habitual physical activity prevent arteriosclerosis related with MTHFR gene variation?

习惯性体力活动是否能预防与MTHFR基因变异相关的动脉硬化？

• 批准号: 20300231
• 负责人: MIYACHI Motohiko
• 金额: $ 12.15万
• 依托单位: National Institute of Health and Nutrition
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20300231/
• 关键词: 習慣的身体活動; ホモシステイン; 動脈硬化; 遺伝子多型; MTHFR; 身体活動; 葉酸; 食事・栄養

The purpose of the cross-sectional study was to examine the associations among MTHFR 677C→T polymorphism, plasma homocysteine (Hcy) concentration, arterial stiffness, and lifestyle (eating habit, fitness, and physical activity).(1) Arterial stiffness and plasma homocysteine in participants with MTHFR677TT genotype were significantly higher than those with CC and TT genotypes.(2) However, there were significant interactions between time spent in light PA (p=0.003), vigorous PA (p=0.001), or inactivity (p=0.004) and MTHFR genotype. In only the TT genotype, shorter time spent in light PA was associated with higher plasma Hcy than a longer time spent in light PA (11.5±3.3nmol/mL vs.8.5±3.3nmol/mL, p<0.001), and longer time spent in vigorous PA and inactivity were associated with higher plasma Hcy (11.8±3.3nmol/mL vs 8.4±3.2nmol/mL, 11.6±3.3nmol/mL vs.8.4±3.3nmol/mL, respectively, p<0.001).(3) Plasma Hcy was significantly different between ≧200 (7.6±0.2nmol/mL) and <200μg/day (8.3±0.3nmol/mL) folate intake groups (p=0.003).(4) The plasma homocysteine level was higher in the TT genotype of MTHFR C677T polymorphism compared with CC and CT genotype individuals. MTHFR C677T polymorphism showed no effect on carotid beta-stiffness, but there was a significant interaction effect between fitness and MTHFR C677T polymorphism on carotid beta-stiffness (P=0.0017). In the Low-Fit subjects, carotid beta-stiffness was significantly higher in individuals with the TT genotype than the CC and CT genotypes. However, there were no such differences in High-Fit subjects.These results imply that CVD risk factors are affected by both genetic and environmental factors. However, further investigations using the larger sample size or longitudinal design will be needed to confirm these findings.

横截面研究的目的是检查MTHFR 677C→T多态性，血浆同型半胱氨酸（HCY）浓度，动脉僵硬和生活方式（饮食，适应性和身体活动）。基因型。（2）然而，时间在光PA（p = 0.003），剧烈PA（p = 0.001）或不活动（p = 0.004）和MTHFR基因型之间存在显着相互作用。仅在TT基因型中，在Light PA上花费的时间较短，与在Light PA上花费的时间更高（11.5±3.3nmol/ml，而8.5±3.3nmol/ml/ml，P <0.001），并且在PA的有力和不活动中花费的时间更长，并且与较高的PLASMA HCY相关（11.8±3.3nmmol/ML/ML/ML/ML/ML/ML/ML/ML/M。 8.4±3.2nmol/ml，11.6±3.3nmol/ml和8.4±3.3nmol/ml，分别为p <0.001）。（3）等离子体HCY显着差异显着差异。 （p = 0.003）。（4）与CC和CT基因型个体相比，MTHFR C677T多态性的TT基因型中血浆同型半胱氨酸水平更高。 MTHFR C677T多态性对颈动脉β-固定性没有影响，但是健身与MTHFR C677T多态性对颈动脉β-固定度之间有显着的相互作用（P = 0.0017）。在低拟合受试者中，TT基因型的个体中的颈动脉β-固醇比CC和CT基因型要高得多。但是，高合适受试者没有这种差异。这些结果表明，CVD危险因素受遗传和环境因素的影响。但是，需要使用较大样本量或纵向设计的进一步研究来确认这些发现。

项目成果

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• 发表时间: 2010
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• DOI: 10.3177/jnsv.55.15
• 发表时间: 2009-02-01
• 期刊: JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
• 影响因子: 1.6
• 作者: Koitaya, Noriko;Ezaki, Junko;Ishimi, Yoshiko
• 通讯作者: Ishimi, Yoshiko