Coronary Circulation-Cardiac Mechanics Coupling

冠状动脉循环-心脏力学耦合

• 批准号: 20300160
• 负责人: MOHRI Satoshi
• 金额: $ 11.81万
• 依托单位: Kawasaki Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20300160/
• 关键词: 収縮能; 拡張能; 冠循環; 心肥大; Caトランスポータ; 心室形熊; 収縮性; 拡張性; カルシウム; 心不全; Na^+-Ca^<2+>交換体; 心機能; 可変弾性モデル; 心臓超音波

In vertebrates, there are two kinds of myocardium, compacta and spongiosa, which are associated with blood supply systems i.e. coronary and sinusoidal circulation. We analyzed the ventricular end-diastolic pressure-volume relationships in rat and frog heart that include integrated expression of chamber geometry and passive material properties of myocardial wall. Frog spongy ventricles showed higher expandability than rat left ventricles composed of compact myocardium. To assess how left ventricular geometry is regulated in heart failure, we generated an animal model of inducible and cardiac specific over-expression of Na^+/Ca^<2+> exchanger (NCX1) which is up-regulated in failing cardiac myocyte. We found that NCX1 over-expressing mice developed concentric hypertrophy with relaxation abnormality.

在脊椎动物中，有两种心肌：致密层和海绵层，它们与血液供应系统（即冠状动脉和窦状循环）相关。我们分析了大鼠和青蛙心脏的心室舒张末期压力-容积关系，包括心室几何形状和心肌壁被动材料特性的综合表达。青蛙海绵状心室比由致密心肌组成的大鼠左心室表现出更高的扩张性。为了评估心力衰竭中左心室几何形状的调节方式，我们生成了Na^+/Ca^2+交换器(NCX1)的可诱导的和心脏特异性过度表达的动物模型，该交换器在衰竭的心肌细胞中上调。我们发现NCX1过度表达的小鼠出现向心肥大并伴有松弛异常。

项目成果

Impairment of leukocyte deformability in patients undergoing esophagectomy.

接受食管切除术的患者白细胞变形能力受损。

• 发表时间: 2009
• 期刊: Clin Hemorheol Microcirc 41(2)
• 作者: Suemori T;Morimatsu H;Mizobuchi S;Morita K;Katanosaka Y;Mohri S;Naruse K
• 通讯作者: Naruse K

The generation of a novel animal of inducible hypertrohy

新型诱导性肥大动物的产生

• 发表时间: 2010
• 作者: Iibuchi S;et al.;Yuki KATANOSAKA
• 通讯作者: Yuki KATANOSAKA

An Experimental Model for Studying Molecular Behavior of Platelet-Endothelial Cell Adhesion Molecule-1 during Mechanical Interactions between Monocytes and Vascular Endothelial Cells.

用于研究单核细胞与血管内皮细胞之间机械相互作用期间血小板-内皮细胞粘附分子-1 分子行为的实验模型。

• 发表时间: 2010
• 期刊: Journal of Biomechanical Science and Engineering
• 作者: 小澤慎也;Ken HASHIMOTO
• 通讯作者: Ken HASHIMOTO

単球の内皮下浸潤により誘発される内皮細胞間隙分子の変化が次の単球浸潤を促進する

单核细胞内皮下浸润诱导的内皮间质分子变化促进随后的单核细胞浸润

• 发表时间: 2010
• 作者: Kawai T;et al.;江渝;橋本謙
• 通讯作者: 橋本謙

Monocyte invasion induces redistribution and subsequent accumulation of endothelial PECAM-1 during para-, but not trans-cellular migration.

单核细胞侵袭在细胞旁迁移过程中诱导内皮 PECAM-1 的重新分布和随后的积累，但不会在跨细胞迁移过程中诱导内皮 PECAM-1 的重新分布和随后的积累。

• 发表时间: 2009
• 作者: Hashimoto K;Kataoka N;Nakamura E;Hagihara K;Okamoto T;Kanouchi H;Minatogawa Y;Mohri S;Tsujioka K;Kajiya F
• 通讯作者: Kajiya F