Detection of Neuronal Loss in Alzheimer Disease Using Magnetization Transfer MR Imaging

使用磁化转移 MR 成像检测阿尔茨海默病中的神经元损失

• 批准号: 10670866
• 负责人: SASAKI Makoto
• 金额: $ 2.18万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670866/
• 关键词: Alzheimer disease; magnetic resonance imaging; magnetization transfer; hippocampus; entorhinal cortex; fast spin echo; short inversion-time inversion recovery; 磁化移動効果

Purpose: To evaluate changes related to the neuronal loss of the hippocampus and the entorhinal cortex in patients with early Alzheimer disease (AD) using high-resolution magnetization-transfer (MT) fast spin-echo (FSE), and fast short inversion-time inversion-recovery (FSTIR) techniques. Methods: Fifteen patients with AD including early stages and ten age-matched normal volunteers were prospectively examined by a 1.5 Tesla superconductive MR scanner (Signal Horizon Lx, GEMS). The pulse sequences we used were FSTIR 4000/120/36 (TR/Tl/Teff) sequence with original optimizations, and proton-density weighted (PDW) FSE 1000/24 (TR/Teeff) sequence with single and multislice acquisitions. In each case, 4 mm thick coronal images through mamillary bodies were obtained with a 17cm field of view and zero-interpolated 512x512 matrices. Signal intensities of the hippocampus, entorhinal cortex, cingulate gyrus, superior temporal gyrus, caudate nucleus, deep white matter, and CSF were measured in sin … More gle-slice and multislice PDW-FSE images. Measurement areas were manually determined on FSTIR images in which gray/white matter contrast was remarkable. The MT ratio (MTR) in each structure was calculated from signal intensities obtained on single/multislice PDW-FSE images, and was normalized by MTR in the caudate nucleus.Results: In all of the cases, measurement areas were readily determined with guidance of FSTIR images. MTRs of the hippocampus and the entorhinal cortex in patients with AD were lower than the control group with statistical significance, whereas those of the other structures indicated no significant alterations.Conclusion: We successfully measured MTRs of the hippocampus and the entorhinal cortex by a combination of single/multislice PDW-FSE and optimized FSTIR techniques. MTRs in the hippocampus and the entorhinal cortex were decreased in early AD, suggesting changes related to the neuronal loss. MT measurements using high-resolution FSE/FSTIR images may help early diagnosis of AD before visible atrophy occurs. Less

目的：使用高分辨率磁化转移（MT）快速自旋回波（FSE）和快速短反转时间来评估早期阿尔茨海默病（AD）患者海马和内嗅皮层神经元损失相关的变化方法：使用 1.5 特斯拉超导 MR 扫描仪对 15 名 AD 患者（包括早期患者）和 10 名年龄匹配的正常志愿者进行前瞻性检查。 （Signal Horizo​​n Lx，GEMS）我们使用的脉冲序列是经过原始优化的 FSTIR 4000/120/36 (TR/Tl/Teff) 序列，以及质子密度加权 (PDW) FSE 1000/24 (TR/Teeff)。 ）单切片和多切片采集序列在每种情况下，通过乳头体获得 4 毫米厚的冠状图像，视野为 17 厘米。零插值 512x512 矩阵在 gle 切片和多层 PDW-FSE 测量区域中测量了海马、内嗅皮层、扣带回、颞上回、尾状核、深部白质和脑脊液的信号强度。在 FSTIR 图像上手动确定，其中灰质/白质对比度显着，每个结构中的 MT 比率 (MTR) 是根据信号计算的。结果：在所有病例中，在患者海马和内嗅皮层的 FSTIR 图像的指导下，很容易确定测量区域。 AD组的MTR值低于对照组，有统计学意义，而其他结构的MTR值没有显着性改变。结论：我们成功测量了海马和内嗅皮层的MTR通过结合单片/多层 PDW-FSE 和优化的 FSTIR 技术，海马和内嗅皮层的 MTR 在早期 AD 中减少，这表明使用高分辨率 FSE/FSTIR 图像进行的 MT 测量可能有助于早期发现。在出现可见萎缩之前诊断 AD 较少。

项目成果

Sasaki M, et al: "MR imaging of substructures in deep gray matters and cerebral cortices."Jap J Clin Radiol. 44. 1229-1234 (1999)

Sasaki M 等人：“深部灰质和大脑皮层亚结构的 MR 成像。”Jap J Clin Radiol。

佐々木真理: "神経系のMR撮像法"日本磁気共鳴医学会誌. 19. 503-509 (1999)

Mari Sasaki：“神经系统的 MR 成像”日本医学磁共振学会杂志 19. 503-509 (1999)。

佐々木真理: "臨床精神医学講座第10巻 精神科臨床における画像診断「Alzheimer型痴呆-MRI」"中山書店 (印刷中). (2000)

Mari Sasaki：“临床精神病学课程第10卷临床精神病学图像诊断阿尔茨海默痴呆-MRI”中山书店（目前正在印刷）（2000年）。

佐々木真理: "MRIによる灰白質内構造の描出"臨床放射線. 44. 1229-1234 (1999)

Mari Sasaki：“通过 MRI 描述灰质的内部结构”《临床放射学》44. 1229-1234 (1999)。

Sasaki M: "Radiologicai analysis of Alzheimer disease using MR imaging."Proc Jap Res Group Senile Dementia. 11. 59-61 (1999)

Sasaki M：“使用 MR 成像对阿尔茨海默病进行放射学分析。”Proc Jap Res Group 老年痴呆症。