Investigation on the association between periodontal disease and silent cerebrovascular lesions in a community-dwelling population.

社区居民牙周病与无症状脑血管病变之间关系的调查。

• 批准号: 19791629
• 负责人: OHI Takashi
• 金额: $ 2.45万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19791629/
• 关键词: 疫学; 歯周病; 無症候性脳血管障害; ラクナ梗塞; 白質病変; 一般住民; 疫学研究; 大迫研究; MRI; パノラマエックス線

The purpose of this cross-sectional cohort study was to examine the association between periodontal disease and silent cerebrovascular lesions. The study cohort comprised 230 individuals at least 55 years of age residing in Ohasama, rural community in northern Japan. Subjects underwent periodontal examination and were classified into 4 groups depending on the periodontal and dentate status (normal/slight, moderate and severe peirodontitis and <10 teeth group). The association between periodontal disease and silent cerebrovascular lesions (white matter hyperintensity and lacunar infarcts) was explored by multivariate logistic regression analysis adjusted for age; gender; body mass index; smoking; alcohol consumption; and a history of hypertension, diabetes, and hypercholesterolemia. The proportions of individuals with silent cerebrovascular lesions gradually increased with a severer periodontal status. The odds ratio for the presence of lacunar infarct in severe periodontal status (OR=12.6) was significantly higher than that in the nomal/slight periodontal status (Reference). This result suggests that periodontal disease may be associated with an increased risk of silent cerebrovascular lesions.

这项横断面研究的目的是检查牙周疾病与无声脑血管病变之间的关联。这项研究队列包括230个人，至少55岁，居住在日本北部的乡村社区。受试者接受牙周检查，并根据牙周和牙齿状态（正常/轻度，中度和严重的胸膜炎，<10齿组）分为4组。通过对年龄调整的多元逻辑回归分析，探索了牙周疾病与无声的脑血管病变（白质高强度和lacunar梗死）之间的关联；性别;体重指数；吸烟；饮酒；以及高血压，糖尿病和高胆固醇血症的病史。静音脑血管病变患者的比例逐渐增加，牙周状态越来越严重。严重牙周状态（OR = 12.6）存在lacunar梗死的优势比明显高于名义/轻微牙周状态（参考）。该结果表明，牙周疾病可能与静音脑血管病变的风险增加有关。

项目成果

Association of Periodontal Disease with Atherosclerosis: the Ohasama Study.

牙周病与动脉粥样硬化的关联：Ohasama 研究。

• 发表时间: 2009
• 作者: S Itabashi;T Ohi;T Murakami;H Mizushiri;M Kikuya;T Ohkubo;J Hashimoto;Y Imai;M Watanabe
• 通讯作者: M Watanabe

Determinants of the Utilization of Dental Services in a Community-Dwelling Elderly Japanese Population

• DOI: 10.1620/tjem.218.241
• 发表时间: 2009-07-01
• 期刊: TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
• 影响因子: 2.2
• 作者: Ohi, Takashi;Sai, Motoyuki;Watanabe, Makoto
• 通讯作者: Watanabe, Makoto

認知症の歯科診療-主治医が知っておくべきこと-

痴呆症的牙科治疗 - 您的医生应该知道什么 -

• 发表时间: 2008
• 期刊: Dementia Japan 22
• 作者: 渡邉誠;坪井明人;大井孝
• 通讯作者: 大井孝

歯周病と脳血管障害

牙周病、脑血管病

• 发表时间: 2008
• 期刊: 財団法人8020推進財団会誌「8020(はち・まる・にい・まる)」 7
• 作者: 渡邉 誠;大井 孝
• 通讯作者: 大井 孝

大阪. 咀嚼が創る健康長寿「噛み合わせと脳」

大阪，咀嚼“咬合脑”创造健康长寿

• 发表时间: 2007
• 作者: 渡邉誠;伊藤進太郎;大井孝
• 通讯作者: 大井孝