The effect of genetic polymor phism on propofol metabolism

基因多态性对丙泊酚代谢的影响

• 批准号: 19791085
• 负责人: TOKINAGA Yasuyuki
• 金额: $ 2.46万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19791085/
• 关键词: 遺伝子多型; プロポフォール; 遺伝子発現; SNP; 薬物代謝; 遺伝子頻度; UDP-Glucuronosvltransferase 1A9; Pharmacogenetics; 一塩基多型

Propofol is widely using anesthetic drug. Propofol is mainly catalyzed by UDP-Glucuronosyltransferase 1A9(UGT1A9). It has been shown that several single nucleotide polymorphisms (SNPs) in regulatory region of UGT1A9 gene are associated with the expression level of UGT1A9 protein. The purpose of this study is to elucidate the relationship between these SNPs and the rate of propofol metabolism in vivo in Japanese population. The blood samples were collected from 50 persons who were living in Wakayama, Japan. Genomic DNA was prepared from each sample. Genotypes of these allele were all wild type.

丙泊酚广泛使用麻醉药。丙泊酚主要由UDP-葡萄糖基转移酶1A9（UGT1A9）催化。已经表明，UGT1A9基因调节区域中的几种单核苷酸多态性（SNP）与UGT1A9蛋白的表达水平有关。这项研究的目的是阐明日本人群中这些SNP与体内丙泊代谢率之间的关系。血液样本是从居住在日本Wakayama的50人那里收集的。从每个样品中制备基因组DNA。这些等位基因的基因型都是野生型。

项目成果

プロポフォール代謝酵素遺伝子における1塩基多型の検討

丙泊酚代谢酶基因单核苷酸多态性检测

• 发表时间: 2010
• 作者: 時永泰行;木本吉紀;小川幸志;谷奥匡;江尻加名子;畑埜義雄
• 通讯作者: 畑埜義雄

The Allelic frequenciea of Propofol-Metabolize Enzyme Gene in Japanese Population

日本人群丙泊酚代谢酶基因等位基因频率

• 发表时间: 2010
• 作者: Yasuyuki Tokinaga;M.D.;Yoshiki Kimoto;M.D.;Kazuhisa Suhimoto;M.D.;Koji Ogawa;M.D.;Yoshio Hatano;M.D.
• 通讯作者: M.D.

The Allelic Frequencies of Propofol-Metabolize Enzyme Gene in Japanese Population

日本人群丙泊酚代谢酶基因的等位基因频率

• 发表时间: 2010
• 作者: Y.Tokinaga;Y.Kimoto;et al.
• 通讯作者: et al.