Study on the pathogenesis of Barrett's esophagus based on stem cell biopsy

基于干细胞活检的Barrett食管发病机制研究

• 批准号: 19590723
• 负责人: KINOSHITA Yoshikazu
• 金额: $ 2.83万
• 依托单位: Shimane University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19590723/
• 关键词: バレット食道; 胃食道逆流症; 幹細胞; 分化; 腸上皮化生; パレット食道; バレット上皮; 杯細胞; 骨髄

We have investigated the pathogenesis of Barrett's esophagus focusing on the cellular origin and abnormal differentiation of the original cells. Esophageal fibroblasts, when exposed to acidic gastric contents, secrete various growth factors and cytokines. Especially HB-EGF produced by these acid exposed fibroblasts induced abnormal differentiation of immature esophageal squamous cells to intestinal type columnar cells by inducing Cdx2 expression. Furthermore squamous epithelial cells exposed to bile acids started to differentiate to columnar epithelial cells by the mutual interaction of Cdx1 and Cdx2.

我们研究了Barrett食管的发病机理，重点是原始细胞的细胞起源和异常分化。食管成纤维细胞暴露于酸性胃含量时，会分泌各种生长因子和细胞因子。特别是由这些酸暴露的成纤维细胞产生的HB-EGF通过诱导CDX2表达来引起未成熟食管鳞状细胞对肠道型柱状细胞的异常分化。此外，暴露于胆汁酸的鳞状上皮细胞通过CDX1和CDX2的相互作用开始与柱状上皮细胞区分开。

项目成果

Architectural roles of multiple chromatin insulators at the human

多个染色质绝缘体在人体中的结构作用

• 发表时间: 2009
• 期刊: EMBO J. 28
• 作者: Mishiro T;et al
• 通讯作者: et al

Half-solidification of nutrient does not decrease

半凝固养分不减少

• 发表时间: 2009
• 期刊: Clin Nutr. 28
• 作者: Adachi K;et al
• 通讯作者: et al

バレット食道および食道腺癌の診断

巴雷特食管和食管腺癌的诊断

• 发表时间: 2008
• 期刊: 治療 90
• 作者: 天野祐二;木下芳一
• 通讯作者: 木下芳一

It is possible to classify non erosive reflux disease(NERD)patients into endoscopically normal group and mininal change group by subjective symptoms and responsiveness to rabeprazole-repont from study with Japanese patients-

根据对日本患者的研究，可以根据主观症状和对雷贝拉唑的反应将非糜烂性反流病（NERD）患者分为内镜正常组和微小变化组

• 期刊: Dig Dis Sci (in press)
• 作者: Kusano M;et. al.
• 通讯作者: et. al.

Barrett's esophagus in Japanese patients: its prevalence, form, and elongation

• DOI: 10.1007/s00535-008-2261-y
• 发表时间: 2008-12-01
• 期刊: JOURNAL OF GASTROENTEROLOGY
• 影响因子: 6.3
• 作者: Okita, Koichi;Amano, Yuji;Kinoshita, Yoshikazu
• 通讯作者: Kinoshita, Yoshikazu