Development of Total Liquid Ventilation System Which Enables Active Medicine Treatment for Serious Patients with Respiratory Failure

开发全液体通气系统，为严重呼吸衰竭患者提供积极的药物治疗

• 批准号: 19300187
• 负责人: FUNAKUBO Akio
• 金额: $ 9.73万
• 依托单位: Tokyo Denki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19300187/
• 关键词: 液体呼吸; 呼吸不全; 能動的治療; 人工肺; ガス交換能; 気道内圧制御; 能動的治療法; Perfluorocarbon; 多目的遺伝アルゴリズム; 完全液体呼吸; 数値流体解析; 重症呼吸不全; 肺コンプライアンス; 液体呼吸; 呼吸不全; 能動的治療; 人工肺; ガス交換能; 気道内圧制御; 能動的治療法; Perfluorocarbon; 多目的遺伝アルゴリズム; 完全液体呼吸; 数値流体解析; 重症呼吸不全; 肺コンプライアンス

The purpose of this study was to develop a Total Liquid Ventilation (TLV) system with high safety which does not damage living lungs. The respiratory conditions in ex-vivo were examined using the Japanese white rabbit for evaluation of the developed TLV system. As a result, the PO_2 and the PCO_2 levels were successfully maintained in normal range, and it was confirmed that the developed TLV system could perform prolonged application.

这项研究的目的是开发具有高安全性的总液体通风（TLV）系统，不会损害活肺。使用日本白兔子检查了前体内的呼吸条件，以评估开发的TLV系统。结果，PO_2和PCO_2级别成功地保持在正常范围内，并确认开发的TLV系统可以执行延长的应用。