Development of surface modification method of titanium implant for rapid bone-bonding

快速骨结合钛种植体表面改性方法的开发

基本信息

批准号：
18592131
负责人：
NAKAGAWA Masaharu
金额：
$ 2.46万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

项目摘要

The authors found that the titanium oxide film which contained small amount Ca in the implant surface was formed by hydrothermal-treating a titanium implant with 10-20mmol/L calcium chloride aqueous solution at 200℃ and then that the generation of the bone-like apatite and initial attachment and proliferation of osteoblast cells were promoted. Moreover, the titanium implant which hydrothermal-treated in the calcium chloride aqueous solution of 10-20mmol/L was implanted in the tibia of the rat, and the connection condition of the implant and the bone was examined.It was shown that the bone-contact ratio was 55% (to be non-treated was 5.7%), 86% (to be non-treated was 19.2%), and 96% (to be non-treated was 57%) of high values after 1, 2, and 4 weeks implantation, respectively. The connective tissue did not intervene between a bone and an implant, and the direct-contact existed at the high rate. Therefore, it was suggested that this treatment was the method which obtained high bond-strength from the early stages after implantation.To examine the bonding strength between the titanium implant and the bone, the hydrothermal-treated implant specimen in calcium chloride solution was implanted in the tibia of the rat and pulling-out test was carried out. The bonding strength of hydrothermal-treatment titanium implant using calcium chloride solution indicated 1N/mm^2 and 1.7N/mm^2 for 1 and 4 weeks after implantation, respectively, and it became clear that the strength of hydrothermal-treated specimen after 1 week was equal to that of non-treated specimen after 4 weeks.This treatment could expect to be the epoch-making surface modification method, with "the resistance of micro-movement at the early stage", "possibility of the load at the early stage", "possibility of the substantial shortening of the healing-up period", and "expression of a high bonding-strength".

作者发现，用10-20mmol/L氯化钙水溶液在200℃下对钛种植体进行水热处理，在种植体表面形成含有少量Ca的氧化钛薄膜，进而生成骨状磷灰石。此外，在氯化钙水溶液中进行水热处理的钛植入物得到促进。将10-20mmol/L植入大鼠胫骨，检查植入物与骨的连接情况，骨接触率为55%（未处理时为5.7%），植入1、2、4周后达到高值的86%（未治疗为19.2%）和96%（未治疗为57%），骨和种植体之间没有结缔组织介入，直接接触率很高，因此表明这种处理是从种植后早期就获得高结合强度的方法。为了检查钛种植体与骨之间的结合强度，将在氯化钙溶液中水热处理的种植体样本植入大鼠胫骨中并进行拔出试验。使用氯化钙溶液的钛种植体在植入后 1 周和 4 周分别显示为 1N/mm^2 和 1.7N/mm^2，并且很明显，经过水热处理的样品在 1 周后的强度与未经过水热处理的样品的强度相同。 -4周后处理的样品。这种处理有望成为划时代的表面改性方法，具有“早期微移动的阻力”、“早期负载的可能性”、 “可大幅缩短愈合时间”和“表现出高粘合强度”。