Development of surface modification method of titanium implant for rapid bone-bonding

快速骨结合钛种植体表面改性方法的开发

基本信息

批准号：
18592131
负责人：
NAKAGAWA Masaharu
金额：
$ 2.46万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

项目摘要

The authors found that the titanium oxide film which contained small amount Ca in the implant surface was formed by hydrothermal-treating a titanium implant with 10-20mmol/L calcium chloride aqueous solution at 200℃ and then that the generation of the bone-like apatite and initial attachment and proliferation of osteoblast cells were promoted. Moreover, the titanium implant which hydrothermal-treated in the calcium chloride aqueous solution of 10-20mmol/L was implanted in the tibia of the rat, and the connection condition of the implant and the bone was examined.It was shown that the bone-contact ratio was 55% (to be non-treated was 5.7%), 86% (to be non-treated was 19.2%), and 96% (to be non-treated was 57%) of high values after 1, 2, and 4 weeks implantation, respectively. The connective tissue did not intervene between a bone and an implant, and the direct-contact existed at the high rate. Therefore, it was suggested that this treatment was the method which obtained high bond-strength from the early stages after implantation.To examine the bonding strength between the titanium implant and the bone, the hydrothermal-treated implant specimen in calcium chloride solution was implanted in the tibia of the rat and pulling-out test was carried out. The bonding strength of hydrothermal-treatment titanium implant using calcium chloride solution indicated 1N/mm^2 and 1.7N/mm^2 for 1 and 4 weeks after implantation, respectively, and it became clear that the strength of hydrothermal-treated specimen after 1 week was equal to that of non-treated specimen after 4 weeks.This treatment could expect to be the epoch-making surface modification method, with "the resistance of micro-movement at the early stage", "possibility of the load at the early stage", "possibility of the substantial shortening of the healing-up period", and "expression of a high bonding-strength".

作者发现，在植入物表面中包含少量Ca的氧化钛膜是通过在200℃处用10-20mmol/l氯化钙水溶液的水热处理钛植入物而形成的，然后促进了骨状的磷灰石和骨状初始附着和骨细胞的生成。此外，在大鼠的胫骨中实现了在氯化钙水溶液中进行热液水溶液的钛植入物，并检查了植入物和骨骼的连接状态。证明该骨骼的连接状态表明，骨接触的比率为55％（未造成55％），为55％（5.7％），为86％（2％）（占86％）（比率为86％）（比率为86％（持续）（均为55％）（均为55％）在植入1、2和4周后，未经处理的高值分别为57％）。连接的组织不干预骨骼和植入物，并且直接接触以高速率存在。因此，建议这种治疗方法是植入后早期从早期阶段获得的高键长的方法。要检查钛植入物和骨骼之间的键合强度，将水热治疗的植入物在氯化钙溶液中植入了大鼠的胫骨和拉力测试中。分别在植入后1和4周，使用氯化钙溶液使用氯化钙植入钛的键合强度表明1N/mm^2和1.7n/mm^2分别在1和4周内，并且很明显，在4周后，未经培训的方法是在1周后进行水热治疗的强度。在早期阶段的微动作”，“早期载荷的可能性”，“恢复时期次要缩短的可能性”和“高粘结强度的表达”。