Research on the transcriptional mechanism of the smooth muscle cell under the vasospasm following subarachnoid hemorrhage

蛛网膜下腔出血后血管痉挛下平滑肌细胞转录机制的研究

• 批准号: 18591602
• 负责人: YOSHIDA Kenji
• 金额: $ 2.34万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591602/
• 关键词: (1)Arterial sclerosis; (2)Cervical carotid artery stenosis; (3)Cerebral artery stenosis; (4)Oxidative stress; (5)Free radical; (6)MRI; (7)Phenotipic modulation; (8)transcription factor; 血管平滑筋細胞; 脱分化

BACKGROUND: Adrenomedullin (AM), a vasorelaxant peptide, is secreted into the cerebrospinal fluid (CSF)from the choroid plexus and can exert natriuretic effects in the kidney. CSF AM concentration is elevated 7-10 days after the onset of aneurysmal subarachnoid hemorrhage (SAH). The aim of the present study was to determine whether CSF AM concentrations correlate with hyponatremia and delayed ischemic neurological deficits (DIND) after SAH. METHODS: CSF and plasma concentrations of AM, brain natriuretic peptide, and atrial natriuretic peptide concentrations were measured in 32 patients with SAH who underwent aneurysmal clipping within 48 h of onset. CSF and blood samples were obtained from these patients during the early period (days 1-3, day 0 being regarded as the day of SAH onset) and the late period (days 8-10). RESULTS: In all patients, AM concentration during the early and late periods was significantly higher in the CSF than in the plasma (p = 0.0028 and p < 0.0001.). In addition, CSF AM concentration was significantly higher during the late period than during the early period (p < 0.0001). Hyponatremia (plasma sodium <135 mmol/l) was present in 11 patients (34.4%) during the late period, and. DIND developed in 6 patients (19%)between day 5 and day 13. Logistic regression analysis demonstrated that late-period CSF AM concentration correlated with hyponatremia and DIND (95% CI: 1.003-1.069, p = 0.0074 and 95% CT 1.003-1.052, p = 0.0108). CONCLUSIONS: The present study demonstrated that CSF AM during the late period following SAH correlates with hyponatremia and DIND.(c) 2008 S. Karger AG, Basel.

背景：肾上腺髓质素（AM）是一种血管舒张肽，从脉络丛分泌到脑​​脊液（CSF）中，可以在肾脏中发挥利尿钠作用。动脉瘤性蛛网膜下腔出血 (SAH) 发病后 7-10 天，CSF AM 浓度升高。本研究的目的是确定脑脊液 AM 浓度是否与 SAH 后低钠血症和迟发性缺血性神经功能缺损 (DIND) 相关。方法：测量了 32 名在发病 48 小时内接受动脉瘤夹闭术的 SAH 患者的脑脊液和血浆 AM、脑钠尿肽和心房钠尿肽浓度。在早期（第1-3天，第0天被视为SAH发病当天）和晚期（第8-10天）从这些患者中采集脑脊液和血液样本。结果：在所有患者中，早期和晚期脑脊液中的 AM 浓度显着高于血浆中的浓度（p = 0.0028 和 p < 0.0001）。此外，CSF AM 浓度在后期显着高于早期 (p < 0.0001)。 11 名患者（34.4%）在晚期出现低钠血症（血浆钠<135 mmol/l）。第 5 天至第 13 天期间，6 名患者 (19%) 出现 DIND。Logistic 回归分析表明，晚期 CSF AM 浓度与低钠血症和 DIND 相关（95% CI：1.003-1.069，p = 0.0074，95% CT 1.003- 1.052，p = 0.0108）。结论：本研究表明 SAH 后晚期的 CSF AM 与低钠血症和 DIND 相关。(c) 2008 S. Karger AG，巴塞尔。

项目成果

くも膜下出血における炎脱接着分子を好感度CRPの意義

CRP有利于火焰灭活分子在蛛网膜下腔出血中的意义

• 发表时间: 2008
• 作者: Kenji Y;et al.;久保 慶高
• 通讯作者: 久保 慶高

Cerebrospinal fluid adrenomedullin concentration correlates with hyponatremia and delayed ischemic neurological deficits after subarachnoid hemorrhage

• DOI: 10.1159/000113734
• 发表时间: 2008-01-01
• 期刊: CEREBROVASCULAR DISEASES
• 影响因子: 2.9
• 作者: Kubo, Yoshitaka;Ogasawara, Kuniaki;Ogawa, Akira
• 通讯作者: Ogawa, Akira

Wrap-clipping with polytetrafluoroethylene for ruptured blisterlike aneurysms of the internal carotid artery

• DOI: 10.3171/jns.2006.105.5.785
• 发表时间: 2006-11-01
• 期刊: JOURNAL OF NEUROSURGERY
• 影响因子: 4.1
• 作者: Kubo, Yoshitaka;Ogasawara, Kuniaki;Ogawa, Akira
• 通讯作者: Ogawa, Akira

Efficacy of Prothrombin complex concentrate for warfarin-related coagulopathy in patients with intracranial hemorrhage

凝血酶原复合物浓缩物治疗颅内出血患者华法林相关凝血病的疗效

• 发表时间: 2007
• 期刊: J Japanese Society for Critical Care Medicine 21
• 作者: Kuniaki;O;Ogasawara K.;Kubo Y.;Kakino S.;Kakino S.;Kashimura H.;Kobayashi M.;久保 慶高;Kashimura H.;Saito H.;Yamazaki T.;Ishigaki D.;Katayama Y.;Fukuda T.;Kashimura H.;Kenji Y
• 通讯作者: Kenji Y

Treatment of vertebral artery aneurysms with transposition of the posterior inferior cerebellar artery to the vertebral artery combined with parent artery occlusion

• DOI: 10.3171/jns.2006.105.5.781
• 发表时间: 2006-11-01
• 期刊: JOURNAL OF NEUROSURGERY
• 影响因子: 4.1
• 作者: Ogasawara, Kuniaki;Kubo, Yoshitaka;Ogawa, Akira
• 通讯作者: Ogawa, Akira