Validation study of sensori-motor fiber somatotopy at semioval center with 3T-MRI based tractography

基于 3T-MRI 纤维束成像的半卵圆中心感觉运动纤维体型验证研究

基本信息

批准号：
18591589
负责人：
HASHIMOTO Naoya
金额：
$ 2.41万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591589/
关键词：
tractography 3-tesla MRI sensori-motor fiber somatotopy electrophysiological monitoring

项目摘要

To validate the sensori-motor fiber somatotopy at semioval center with 3T-MRI based fiber tractography, we conducted the following study and obtained the results as followings.1. In a total of 20 normal volunteers and patients, diffusion tensor imaging (DTI) was obtained by a 3T-MRI scanner. In the procedure, we standardized the MR parameters on DTI in the scanner, and appropriate parameters were set as slice thickness of 2.6mm, motion probing gradient of 25 axes and b-value of 2000. By putting 3 regions of interest (ROI) on the primary motor and sensory cortices, we could delineate motor and sensory fibers innervating to upper extremity, trunk and lower extremity separately. Fiber tractography delineating three major bundles separately were exported as DICOM images and utilized on surgical nerro-navigator.2. We compared those anatomical ROIs with functional cortical structure obtained by functional MRI and magnetoencephalography (MEG) in 15 patients. In fourteen patients, those anatomically defined ROIs for fiber tractography were compatible with functional data. We observed one patient with diffuse astrocytoma arising from primary motor area, in whom fractional center was thought to have slightly moved from anatomically defined center. In most of cases, we can define the ROIs anatomically for fiber tractography, however, in some instances like slowly growing tumors, we need to use functional data from fMRI or MEG to set ROIs for fiber tractography.3.In 5 patients who underwent eloquent surgery for the lesions close to semioval center, validation study was conducted by comparing 3T-MRI fiber tractography on navigational system with electrophysiological study by sensory and motor evoked potentials (SEP and MEP). In 4 patients in whom SEP and MEP were trustable, sensori-motor fiber somatotopy obtained by fiber tractography was successfully validated.

为了用基于3T-MRI的纤维拖拉术在半分发中心验证Sensori-Motor纤维体育纤维，我们进行了以下研究，并获得了以下结果。1。在共有20名正常志愿者和患者中，3T-MRI扫描仪获得了扩散张量成像（DTI）。在该步骤中，我们将扫描仪中DTI上的MR参数标准化，并将适当的参数设置为2.6mm的切片厚度，运动探测25轴的运动梯度和2000年的B值。通过将3个感兴趣的区域（ROI）放在一级运动和感觉皮层上的3个区域（ROI）（ROI），我们可以分离出较高的运动和感觉较大的高度极端性，并降低了较高的极端性，且较低的层次和较高的层次和较高的层次和较高的层次。将三个主要捆绑包分别导出为DICOM图像，并用于手术nerro-navigator.2。我们将15例患者的功能性MRI和磁脑化（MEG）获得的功能性皮质结构进行了比较。在14例患者中，那些解剖学上定义的用于纤维拖拉机的ROI与功能数据兼容。我们观察到一名由原发性运动区域引起的弥漫性星形细胞瘤的患者，其中分数中心从解剖学上定义的中心略有移动。在大多数情况下，我们可以在解剖学上定义ROI用于纤维拖拉术，但是，在某些情况下，在某些情况下，我们需要使用fMRI或MEG的功能数据将ROI设置为纤维拖拉机的ROI。在5例患者中，对经过验证的病变进行了远距离研究，通过对验证的远程研究进行了良好的手术，该系统通过验证中心进行了验证，通过比较3TT TRACTICARCHIC，以比较3TT TT TT TT TT TT，通过感官和电机引起的电势（SEP和MEP）。在4例SEP和MEP可信赖的患者中，通过纤维拖拉机获得的感觉运动纤维体育型已成功验证。