Development of image diagnostic system for upper airway using high dimensional imaging data and Establishment of diagnostic standard criteria.

利用高维影像数据开发上呼吸道影像诊断系统并建立诊断标准。

• 批准号: 18390501
• 负责人: KOBAYASHI Kaoru
• 金额: $ 9.72万
• 依托单位: Tsurumi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390501/
• 关键词: Diagnostic Radiology; Obstructive sleep apnea(OSA); 閉塞性睡眠時無呼吸症候群; 上気道; 画像診断; Computed Tomography; Polysomonography; 高次元画像; Polysomnography; 無作為割付試験

Obstructive sleep apnea (OSA) is a disorder characterized by repetitive upper airway collapse during sleep. Identifying the exact location of the obstruction is important to obtain an effective treatment. For many years 2-dimensional (2D) cephalometric images have been used to look for anatomic differences between OSA patients and normal subjects (non-OSA), and researchers have reported significant craniofacial differences such as size and position of the mandible, posterior airway space enlargement, and in the size of the tongue and soft palate. While 2D imaging is valuable, the complex shape of the airway is not fully appreciated except with 3D images and nature of the obstruction in obstructive sleep apnea (OSA) patients. Ten OSA patients and 10 non-OSA control subjects were imaged using conebeam computed tomography to compare their upper airway structure.This project have four phases of following steps : 1. The systems construction of the high-dimensional image data, 2. The decision of the clinical item, 3. Examination of the diagnosis accuracy by the randomized controlled trial, 4. The establishment of the diagnostic criteria.The following conclusions were provided about the OSA patients :(1) we demonstrate the utility of diagnosis of anatomy with the 3D airway imaging with CBCT in awake patients in the supine position ; (2) we show the characteristics of OSA airway that may contribute to distinguishing OSA cases from non-OSA cases.

阻塞性睡眠呼吸暂停（OSA）是一种以睡眠期间反复上呼吸道塌陷为特征的疾病。确定阻塞的确切位置对于获得有效的治疗非常重要。多年来，二维 (2D) 头影测量图像一直用于寻找 OSA 患者和正常受试者（非 OSA）之间的解剖学差异，研究人员报告了显着的颅面部差异，例如下颌骨、后气道空间的大小和位置扩大，以及舌头和软腭的大小。虽然 2D 成像很有价值，但除了 3D 图像和阻塞性睡眠呼吸暂停 (OSA) 患者的阻塞性质外，我们还无法完全了解气道的复杂形状。使用锥束计算机断层扫描对 10 名 OSA 患者和 10 名非 OSA 对照对象进行成像，以比较他们的上呼吸道结构。该项目分为以下四个阶段：1. 高维图像数据的系统构建，2. 决策临床项目，3.通过随机对照试验检验诊断准确性，4.诊断标准的建立。关于OSA患者提供以下结论：（1）我们证明了解剖学诊断的效用对仰卧位的清醒患者进行 CBCT 3D 气道成像； (2) 我们展示了 OSA 气道的特征，这可能有助于区分 OSA 病例和非 OSA 病例。

项目成果

Gender and age-based differences in computed-tomography measurements of the orophaynx

口咽部计算机断层扫描测量中基于性别和年龄的差异

• 发表时间: 2008
• 期刊: Oral Surg Oral Med Oral Pathol Oral Radiol Endod DOI:10.1016/j.tripleo(In press)
• 作者: Yuko Shigeta;Takumi Ogawa;Jaqueline Venturin;et. al.
• 通讯作者: et. al.

Evaluation of cross-section airway configuration of obstructive sleep apnea

• DOI: 10.1016/j.tripleo.2006.06.008
• 发表时间: 2007-01-01
• 期刊: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
• 作者: Ogawa, Takumi;Enciso, Reyes;Clark, Glenn T.
• 通讯作者: Clark, Glenn T.

The influence of age and BMI on interverfebral disc height and oropharyngeal airway in Japanese men and women

年龄和BMI对日本男性和女性椎间盘高度和口咽气道的影响

• 发表时间: 2008
• 期刊: Int J CARS DOI:10.1007/s11548-008-0204-y(In press)
• 作者: Yuko Shigeta;Takumi Ogawa;Jaqueline Venturin;et. al.
• 通讯作者: et. al.

The Oral Appliance Therapy with OSA Patient Using X-ray Image

利用 X 射线图像对 OSA 患者进行口腔矫治器治疗

• 发表时间: 2007
• 作者: Shigeta Y;Enciso R;Ogawa T;Clark GT.;Takumi Ogawa
• 通讯作者: Takumi Ogawa

Effectiveness of high dimensional CT imaging of obstructive sleep apnea and temporomandibular disorders patients.

高维 CT 成像对阻塞性睡眠呼吸暂停和颞下颌疾病患者的有效性。

• 发表时间: 2006
• 作者: Kaoru Kobayashi;Special lecture
• 通讯作者: Special lecture