Survey on human contamination by brominated flame retardants and chlorinated/brominated dioxins for the health risk factor of mother and child

溴化阻燃剂和氯化/溴化二恶英对人体的污染及母婴健康危险因素调查

基本信息

批准号：
18390202
负责人：
OHTA Souichi
金额：
$ 4.67万
依托单位：
Setsunan University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

项目摘要

In order to clear human exposure by Co-PXBs, it was investigated the Co-PXBs concentration in the breast milk (sampling day; 5 and 30 days) of Japanese multiparae and primiparae. The concentration of Co-PXBs ranged between 0.42 and 1.41 pg TEQ/g lipid, and this observation is our first finding for human exposure by Co-PXBs. With respect the average TEQ level in mother's milk, there is no difference between of multiparae and primiparae, not in the case of CO-PCBs. Interestingly, when the level of Co-PCBs at 5 and 30 days of same woman was compared, that at 5 days-breast milk samples were higher than that at 30days-samples for almost sample analyzed. However, in the case of CO-PXBs, such tendency was not always observed.Then, the abundant congeners of Co-PXBs were #126A, #126 B and #169, and it was estimated that human exposure by this Co-PXBs #126B is derived from the eating of fish. Then, it was compared the contribution ratio of four kinds of dioxin analogues for total TEQ concentration in mother's milk of Japan. Major analogues were PCDDs/DFs, Co-PCBs and Co-PXBs, and PXDDs/DFs were negligible level, showing unexpected high contribution ratio of Co-PXBs in the breast milk of multiparae. As there are theoretically more few hundreds congeners in the Co-PXBs group, and therefore it needs further detail survey of Co-PXBs contaminationFurther study is warranted to evaluate whether Co-PXBs exposures to nursing infants pose a health risk. Additional investigations of Co-PXBss in the daily foods are warranted to better understand the nature and extent of Co-PXBs contamination of Japanese food supply.

为了明确人体对Co-PXBs的暴露情况，对日本经产妇和初产妇的母乳（取样日；5天和30天）中的Co-PXBs浓度进行了调查。 Co-PXB 的浓度范围在 0.42 至 1.41 pg TEQ/g 脂质之间，这一观察结果是我们首次发现 Co-PXB 人类暴露情况。就母乳中的平均TEQ水平而言，经产妇和初产妇之间没有差异，而CO-PCBs则没有差异。有趣的是，当比较同一女性第 5 天和第 30 天的 Co-PCB 水平时，几乎分析的样本中，第 5 天母乳样本的 Co-PCBs 水平高于第 30 天样本的 Co-PCBs 水平。然而，就CO-PXB而言，并不总是观察到这种趋势。然后，Co-PXB的丰富同源物是#126A、#126 B和#169，并且估计人类接触该Co-PXB# 126B源自吃鱼。然后比较了四种二恶英类似物对日本母乳中总TEQ浓度的贡献率。主要类似物是PCDDs/DFs、Co-PCBs和Co-PXBs，PXDDs/DFs的水平可以忽略不计，显示Co-PXBs在经产妇母乳中的贡献率出人意料地高。由于Co-PXBs理论上有数百个同系物，因此需要对Co-PXBs污染进行进一步的详细调查，需要进一步研究来评估Co-PXBs暴露给哺乳婴儿是否构成健康风险。有必要对日常食品中的 Co-PXBss 进行进一步调查，以更好地了解日本食品供应中 Co-PXBs 污染的性质和程度。