High-speed preparation of biocompatible ceramic coatings by laser CVD

激光CVD高速制备生物相容性陶瓷涂层

基本信息

批准号：
18360310
负责人：
GOTO Takashi
金额：
$ 10.64万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18360310/
关键词：
biocompatible ceramic coatings laser CVD

项目摘要

In the present study, calcium base oxides, e.g. CaTiO_3, α-TCP and HAp films were prepared by metalorganic chemical vapor deposition (MOCVD) and laser enhanced CVD (LCVD). Effects of preparation conditions on the crystal phase, microstructure and deposition rate were investigated. Furthermore, the bone conductivity and biocompatibility were evaluated by the formation behavior of apatite on those films in a Hanks'' solution.CaTiO_3, α-TCP and HAp films were obtained first by MOCVD. Apatite wholly covered the surface of CaTiO_3 films with a smooth surface after 6 weeks, CaTiO_3 films with a complicated surface after 3 days, α-TCP films after 2 weeks and HAp films after 6 hours. The apatite predominantly formed at the micro-sized hollows, indicating significant effect of surface morphology on the apatite formation rate except of the intrinsic bone conductivity of the ceramics films.HAp and α-TCP films were obtained also by LCVD at a high deposition rate. Laser power (P_L) showed significant effect on the crystal phase of Ca-P-O films: at P_L=200W α-TCP formed in wide conditions, at P_L=150W α-TCP formed at high temperatures and HAp formed at low temperatures, at P_L=100W HAp in a main phase formed in wide conditions. Any film showed a dense microstructure. The deposition rate increased with increasing the precursor concentration, deposition temperature, laser power and total pressure in chamber (P_<tot>), showing the highest value of 1200μm/h at P_L=200W and P_<tot>=0.6 kPa. Apatite formed on the Hap films prepared by LCVD in Hanks'' solution after 6 hours.In a summary, it is confirmed that CaTiO_3, α-TCP and HAp films can be prepared by chemical vapor deposition, and the effects of preparation conditions on the crystal phase, microstructure and deposition rate were clarified. The CaTiO_3, α-TCP and HAp films prepared by CVD were proved to have excellent bone conductivity by revealing high apatite formation rate in pseudo body solutions.

在演讲研究中，钙碱氧化物，例如CATIO_3，α-TCP和HAP膜是通过金属有机化学蒸气沉积（MOCVD）和激光增强的CVD（LCVD）制备的。研究了制备条件对晶体相，微结构和沉积速率的影响。此外，通过MOCVD首先通过MOCVD获得了CATIO_3，α-TCP和HAP膜，通过在汉克斯的溶液中这些膜上的磷灰石的形成行为来评估骨电导率和生物相容性。 6周后，磷灰石完全覆盖了Catio_3膜的表面，表面光滑，3天后的Catio_3膜具有复杂的表面，2周后α-TCP膜和6小时后的HAP膜。主要是在微型空心处形成的磷灰石，表明表面形态对磷灰石形成速率的显着影响，除了陶瓷膜的固有骨电导率。HAP和α-TCP膜也通过LCVD以高沉积速率获得。激光功率（P_L）对CA-P-O膜的晶相显示出显着影响：在较广泛的条件下形成的P_L =200Wα-TCP，在P_L =150Wα-TCP下，在高温下形成，在低温下形成的HAP，在P_L = 100W HAP时，在较广泛的条件下，在P_L = 100W HAP。任何电影都显示出密集的微观结构。沉积速率随着前体浓度，沉积温度，激光功率和腔室的总压（P_ <tot>）的增加而增加，显示在p_l = 200W时的最高值为1200μm/h，P_ <tot> = 0.6 kPa。 6小时后，由LCVD在Hanks'溶液中制备的HAP膜上形成的磷灰石。在摘要中，可以通过化学蒸气沉积来制备CATIO_3，α-TCP和HAP膜，以及制备条件对晶体相，微结构和深度速度速率的影响。通过揭示伪体溶液中的高磷灰石形成速率，通过CVD制备的CATIO_3，α-TCP和HAP膜具有出色的骨电导率。