Analysis of neuronal network for temperature regulation.

温度调节神经网络分析。

基本信息

批准号：
07044260
负责人：
KANOSUE Kazuyuki
金额：
$ 4.1万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07044260/
关键词：
thermo regulation neuronal network set point hypothalamus nitric oxide

项目摘要

The body temperature of homeothermic animal is controlled by multiple autonomic and behabioral responses and themoreceptors are distributed throughout the body. This multiple input-output system is regulated by the central nervous system, on the top of which the hypothalamus uncluding the preoptic area is located. The neuronal network for thermoregulation has been investigated by stimulation and ablation of the brain, and the importance of the hypothalamus became apparent. In spite of the flourishing outcome of single unit studies, there is almost no advance in our knowledge of the thermoregulatory "network", which makes it difficult to link electrophysiological and pharmachological data directly with thermoregulatory responses observed in whole animals. We don't know yet, for example, what groups of neuron are working for control of each effector response, and where they send efferent signals. This project was planned to connect this "missing link" in the study of thermoregulation. Fi … More rst, we analyzed efferent projection from the proptic area for thermoregulatory vasomotion. Electrophisilogical and ablation study revealed that warm sensitive neurones of the preoptic area send (1) inhibitory signals to the ventral tegmental area and (2) excitatory signals to the PAG for thermoregulatory vasomotor bontrol. Next the results of electrical stimulations had long ago showed that the posterior hypothalamus (PH) is important for the control of shivering, but it was not clear whether it was neurons that ware stimulated or it is only passing fibers. We found that cold-induced shivering was suppressed aftor muscimol, an agonist of the GABAa receptor, was injected into the PH,which therefore must contain neurons that send excitatory signals that elicit shivering. But PO warm-sensitive neurons may send inhibitory signals directly to a lower neuronal structure, bypassing the PH,since PO warming has been found to suppress shivering in animals whose PH was isolated from other hypothalamus. Less

恒温动物的体温由多种自主和行为反应控制，并且温度感受器分布在整个身体中，这种多输入输出系统由中枢神经系统调节，下丘脑（不包括视前区）位于中枢神经系统的顶部。通过刺激和消融大脑来研究温度调节的神经网络，下丘脑的重要性变得显而易见，尽管单个单元的研究取得了蓬勃的成果，但在这方面几乎没有任何进展。我们对体温调节“网络”的了解使得我们很难将电生理学和药理学数据与在整个动物中观察到的体温调节反应直接联系起来，例如，我们还不知道哪些神经元组在控制每个效应器反应。，以及它们发送传出信号的地方。这个项目计划连接体温调节研究中的这个“缺失的环节”。首先，我们分析了温度调节血管运动的传出区域。电生理学和消融研究表明，视前区的温敏感神经元向腹侧被盖区发送抑制信号，(2) 向 PAG 发送兴奋信号，以控制温度调节血管舒缩。后丘脑（PH）对于控制颤抖很重要，但我们发现刺激的是神经元还是只是传递纤维尚不清楚。寒冷引起的颤抖在将 GABAa 受体激动剂蝇蕈醇注射到 PH 中后被抑制，因此 PH 中必定包含发送引起颤抖的兴奋信号的神经元，但 PO 热敏感神经元可能直接向较低的神经元发送抑制信号。神经元结构，绕过 PH，因为 PO 变暖已被发现可以抑制 PH 与其他下丘脑分离的动物的颤抖。