Signal cording and target net work of spatial disorientation in the brain

大脑空间定向障碍的信号编码和目标网络

• 批准号: 17390462
• 负责人: TAKEDA Noriaki
• 金额: $ 9.28万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17390462/
• 关键词: Spatial disorientation; Motion sickness; Histamine; Histamine HI receptors; hypergravity; pica

We have developed an animal model of motion sickness, using pica as a behavioral index of motion sickness in rats. Rats cannot vomit, but pica, the ingestion of non-nutritive substances such as kaolin (hydrated aluminum silicate), is an illness-response behavior, which is analogous to vomiting. After 2-hours load of 2g hypergravity, rats ate a significant amount of kaolin, indicating that they suffered from motion sickness. The hypergravity-induced kaolin intake was suppressed by mepyramine, an H1 antagonist, but not by zolantizine, an H2 antagonist. A 2-h load of 2g hypergravity also transiently increased the release of histamine in the rat hypothalamus measured by in vivo brain microdialysis. These findings suggested that the activation of the central histaminergic neuron systems after hypergravity induces motion sickness via H1 receptors (H1R).Then, to investigate changes in post-synaptic events in the development of motion sickness, gene expression of H1R in the rat hypothalamus was examined using a real-time PCR method after hypergravity. The expression of H1R mRNA in the rat hypothalamus was significantly increased after 2g hypergravity for 2 hours, indicating an up-regulation of H1R induced by hypergravity. Taken together with the previous finding demonstrating an activation of the histaminergic neurons after hypergravity, the present finding further indicate an amplification of the H1 transmission in the development of motion sickness,. The up-regulation of H1R may contribute to the built up characteristic of motion sickness symptoms, which developed gradually at first and then progressed rapidly.

我们使用PICA作为大鼠运动疾病的行为指数开发了一种动作疾病的动物模型。大鼠不能呕吐，但是PICA是摄入非营养物质（例如高岭土（水合硅酸盐））的疾病反应行为，类似于呕吐。 2小时的2G高度负荷后，大鼠吃了大量高岭土，表明它们患有疾病。 H1拮抗剂H1拮抗剂Mepyramine抑制了高度诱导的高岭土摄入量，而H2拮抗剂Zolantizine却没有抑制。 2-h载荷2G超增强性也瞬时增加了通过体内脑微透析测量的大鼠下丘脑中组胺的释放。这些发现表明，超高实现后中央组胺能神经元系统的激活通过H1受体（H1R）诱导运动疾病。 2G超增强性2小时后，H1R mRNA在大鼠下丘脑中的表达显着增加，表明由高度诱导的H1R上调。与先前的发现一起证明了超级实现后的组胺能神经元的激活，目前的发现进一步表明了在运动疾病发展中H1传播的扩增。 H1R的上调可能有助于运动疾病症状的积累特征，该症状首先逐渐发展，然后迅速发展。

项目成果

Natural history of benign paroxysmal positional vertigo and efficacy of Epley and Lemtert maneuvers.

良性阵发性位置性眩晕的自然史以及 Epley 和 Lemtert 演习的功效。

• 发表时间: 2006
• 期刊: Otolaryngol Head Neck Surg 135
• 作者: 森野 茂行;他;大森 孝一;Omori K;中村達雄;K.Sekine
• 通讯作者: K.Sekine

Prognosis of inner ear periphery and central vestibular plasticity in sudden deafness with vertigo

• DOI: 10.1177/000348940511401008
• 发表时间: 2005-10-01
• 期刊: ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
• 影响因子: 1.4
• 作者: Kitahara, T;Takeda, N;Kubo, T
• 通讯作者: Kubo, T

Effects of Immersion in virtual reality on posture control

虚拟现实沉浸对姿势控制的影响

• 发表时间: 2005
• 期刊: Neurosci.Lett. 379
• 作者: 森野 茂行;他;大森 孝一;Omori K;中村達雄;K.Sekine;T.Kitahara;M.Ando.;H.Akizuk.
• 通讯作者: H.Akizuk.