Functicnal significance of the medial paiietal areas for the cognitive map and navigation

内侧顶叶区域对于认知图和导航的功能意义

• 批准号: 17300131
• 负责人: TAIRA Masato
• 金额: $ 6.07万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17300131/
• 关键词: Cognitive map; Parietal Cortex; Monkey; Navigation; Route knowledge; 機能的MRI; Cognitive map; Parietal Cortex; Monkey; Navigation; Route knowledge; 機能的MRI

A cognitive map is a stored representation of a large-scale environment in the brain. When we behave in a large-scale environment, a cognitive map is necessary but not sufficient ; because it is too abstract to plan a specific route map for our navigation. When we drive to our office, we can take the correct route subconsciously, making a turn or going straight at each intersection. This phenomenon suggests we may have an internal list of what we have to do at a given location in addition to a "cognitive map" in our brain. This internal list is known as "route knowledge" and is accessed to be able to navigate ourselves in a large-scale environment. Lesion and neuroimaging studies of humans suggest that the medial parietal region (MPR), including the retrosplenial and posterior cingulate cortices, is critically involved in navigation based on route knowledge. To study the neural mechanisms of navigation in a large environment in primates, a large environment within the experimental setu … More p needs to be built. In this study, we used a virtual reality technique to overcome this problem and recorded a single unit activity from the monkey MPR while the monkey navigated in the virtual environment without performing any actual movement.To examine the neural basis of route knowledge by which one can reach one's destination, we recorded the activity of 580 neurons in the monkey medial parietal region (MPR) while monkeys actively navigated through a virtual environment. One hundred eighty of these neurons (31%) showed significant responses to the monkeys' movements in the virtual environment. Of these responsive neurons, 77% (139-180) showed responses associated with a specific movement at a specific location (navigation neurons), 8% (14-180) showed responses associated with a specific movement (movement- selective neurons), and the remaining 27 neurons (15%) were nonselective. We found navigation neurons whose responses to the same movement at the same location were modulated depending on the route that the monkey was currently taking, that is, in a route-selective manner (32 of 59 tested neurons among 139 navigation neurons, route-selective navigation neurons. The reversible inactivation of MPR neurons by muscimol resulted in a monkey becoming lost during the navigation task trial. These results suggest that MPR plays a critical role in route-based navigation by integrating location information and self-movement information. Less

认知图是大脑中大规模环境的存储表示。当我们在大规模的环境中行事时，认知图是必要的，但不够。因为它太抽象了，无法为我们的导航计划特定的路线图。当我们开车去办公室时，我们可以在下意识地走正确的路线，在每个十字路口转弯或直行。这种现象表明，除了大脑中的“认知图”外，我们可能会在给定位置要做的事情内部列表。该内部列表被称为“路线知识”，可以在大规模的环境中访问自己。人类的病变和神经影像学研究表明，培养基顶部区域（MPR），包括后泛事实和后扣带回皮质，基于途径知识非常参与导航。为了研究灵长类动物的大环境中导航的神经元机制，实验性setu中的大环境……需要建立更多的p。 In this study, we used a virtual reality technique to overcome this problem and recorded a single unit activity from the monkey MPR while the monkey navigation in the virtual environment without performing any actual movement.To examine the neuronal basis of route knowledge by which one can reach one's destination, we recorded the activity of 580 neurons in the monkey media parietal region (MPR) while monkeys actively navigation through a virtual environment.这些神经元中的一百八十（31％）对猴子在虚拟环境中的运动表现出明显的反应。在这些反应性神经元中，有77％（139-180）显示了与特定位置（导航神经元）特定运动相关的响应，8％（14-180）显示与特定运动（运动选择性神经元）相关的响应，其余27个神经元（15％）不起作用。 We found navigation neurons whose responses to the same movement at the same location were modulated depending on the route that the monkey was currently taking, that is, in a route-selective manner (32 of 59 tested neurons among 139 navigation neurons, route-selective navigation neurons. The reversible inactivation of MPR neurons by muscimol resulted in a monkey becoming lost during the navigation task trial. These results suggest that MPR plays a critical通过集成位置信息和自动移动信息，在基于路线的导航中的角色