Analyses of Molecular Assembly and Diversity of Proteasomes
蛋白酶体的分子组装和多样性分析
基本信息
- 批准号:17002019
- 负责人:
- 金额:$ 411.42万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Specially Promoted Research
- 财政年份:2005
- 资助国家:日本
- 起止时间:2005 至 2009
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The proteasome is an unusually large cellular apparatus that selectively degrades unnecessary proteins, which must be eliminated from the cells. We defined the molecular mechanisms underling proteasome assembly by the findings of a set of proteasome-dedicated molecular chaperones that assist the correct formation of the proteasome. In addition, we established the new concept on the diversity of the proteasome. Previously, we discovered the "immunoproteasome", which emphasized the specialized functions in immune responses. Lately, we also identified another unique "thymoproteasome", which is expressed exclusively in the thymus. We found that thymoproteasome-deficient mice displayed defective thymic development of CD8+T cells, suggesting a key role for thymoproteasome in the development of the MHC class I-restricted CD8+T cell repertoire during thymic positive selection.
蛋白酶体是一种异常大的细胞设备,有选择地降解不必要的蛋白质,必须从细胞中消除。我们通过发现一组蛋白酶体至少的分子伴侣的发现来定义蛋白酶体组装下的分子机制,以帮助蛋白酶体的正确形成。此外,我们还建立了有关蛋白酶体多样性的新概念。以前,我们发现了“免疫蛋白酶体”,它强调了免疫反应中的专业功能。最近,我们还确定了另一个独特的“肺瘤”,该“甲状腺蛋白酶体”仅在胸腺中表达。我们发现,胸骨蛋白酶体缺乏小鼠表现出CD8+T细胞的胸腺胸腺不良发育,这表明胸腺蛋白酶体在胸腺阳性选择过程中MHC I限制的CD8+T细胞库的发育中起着关键作用。
项目成果
期刊论文数量(122)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The proteasome: overview of structure and functions.
蛋白酶体:结构和功能的概述。
- DOI:10.2183/pjab.85.12
- 发表时间:2009
- 期刊:
- 影响因子:0
- 作者:Tanaka K
- 通讯作者:Tanaka K
Unexpected encounter with immunity during my proteasome study
蛋白酶体研究中意外遭遇免疫
- DOI:
- 发表时间:2008
- 期刊:
- 影响因子:0
- 作者:Yamano T.;et. al.;田中啓二;Keiji Tanaka;Keiji Tanaka;Keiji Tanaka;田中啓二;Keiji Tanaka;Keiji Tanaka
- 通讯作者:Keiji Tanaka
オートファジー(Self-eating)と神経変性疾患
自噬(自食)和神经退行性疾病
- DOI:
- 发表时间:2007
- 期刊:
- 影响因子:0
- 作者:曽 友深;他;村田 茂穂;田中 啓二;田中 啓二;田中 啓二
- 通讯作者:田中 啓二
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TANAKA Keiji其他文献
A role of the lateral prefrontal cortex in the congruency sequence effect revealed by transcranial direct current stimulation
外侧前额叶皮层在经颅直流电刺激揭示的一致性序列效应中的作用
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:3.7
- 作者:
LI Nan;WANG Ying;JING Fang;ZHA Rujing;WEI Zhengde;YANG Li-Zhuang;GENG Xiujuan;TANAKA Keiji;ZHANG Xiaochu - 通讯作者:
ZHANG Xiaochu
TANAKA Keiji的其他文献
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{{ truncateString('TANAKA Keiji', 18)}}的其他基金
Cell Biology of Proteasomes
蛋白酶体的细胞生物学
- 批准号:
19H00997 - 财政年份:2019
- 资助金额:
$ 411.42万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
The Proteasome: Mechanistic Actions and In-depth Physiopathological Analyses
蛋白酶体:机制作用和深入的病理生理学分析
- 批准号:
26000014 - 财政年份:2014
- 资助金额:
$ 411.42万 - 项目类别:
Grant-in-Aid for Specially Promoted Research
Polymer Function Based on Hierarchical Dynamics at Non-equilibrium Interfaces
基于非平衡界面层次动力学的聚合物函数
- 批准号:
24350061 - 财政年份:2012
- 资助金额:
$ 411.42万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Four-dimensional Mapping of Local Viscoelastic Functions: A Proposal for the Picture of Hierarchical Heterogeneity in Physical Properties of Polymers
局部粘弹性函数的四维映射:聚合物物理性质层次异质性图的提议
- 批准号:
23655106 - 财政年份:2011
- 资助金额:
$ 411.42万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
In-depth Analysis of Proteasome-Mediated Regulatory Proteolysis
蛋白酶体介导的调节蛋白水解的深入分析
- 批准号:
21000012 - 财政年份:2009
- 资助金额:
$ 411.42万 - 项目类别:
Grant-in-Aid for Specially Promoted Research
Structure and Physical Properties of Polymers at Nanoscale Interface with Liquids
聚合物与液体纳米级界面的结构和物理性质
- 批准号:
21685013 - 财政年份:2009
- 资助金额:
$ 411.42万 - 项目类别:
Grant-in-Aid for Young Scientists (A)
Functional division in the prefrontal cortex during goal-directed behavior utilizing behavioral rules
利用行为规则进行目标导向行为时前额皮质的功能划分
- 批准号:
19200027 - 财政年份:2007
- 资助金额:
$ 411.42万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Mechanism of ultimate recording density in nano-scale phase-change memories
纳米级相变存储器的极限记录密度机制
- 批准号:
18560001 - 财政年份:2006
- 资助金额:
$ 411.42万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Understanding and Prediction of Nano-physical Properties for Polymers Based on Combinatorial Method
基于组合方法的聚合物纳米物理性质的理解和预测
- 批准号:
18685014 - 财政年份:2006
- 资助金额:
$ 411.42万 - 项目类别:
Grant-in-Aid for Young Scientists (A)
Roles of inferotemporal cortex in visual object recognition and their mechanisms
颞下皮层在视觉物体识别中的作用及其机制
- 批准号:
17022047 - 财政年份:2005
- 资助金额:
$ 411.42万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
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