Study on the effect of mastication on memories and leaning-A possibility of trigger factor of dementia-

咀嚼对记忆和学习影响的研究-痴呆触发因素的可能性-

• 批准号: 16500468
• 负责人: SATO Chie
• 金额: $ 2.1万
• 依托单位: National Institute of Advanced Industrial Science and Technology (2007)Tokyo Metropolitan Organization for Medical Research (2004-2006)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16500468/
• 关键词: brain, nerve; near infrared spectroscopy (NIRS); mastication; cerebral blood flow change; aging; neuroscience; dementia; 計測工学; 近赤外分光計測; 認知・記憶; 記憶; 認知症(痴呆症)

Recently, some researchers have reported the possibility that impairment of ability for mastication was one of the trigger factors of dementia. There are, however, only a few studies on the relationship between mastication and cognitive function. The aim of this study is to investigate the relationship between mastication and hemodynamics, which is the first step toward our health care and the prevention of some neurological diseases.First, for selective monitoring of the cerebral perfusion, we studied some characteristics of optical signals measured from the human head by near-infrared spectroscopy(NIRS), which has some advantages over other methods in terms of, for example, the measurement under sitting on the seat. We clarified the usefulness and limitations of the NIRS(time-resolved spectroscopic method) for monitoring of cerebral hemodynamics.Next, we examined Hb concentration changes evoked by chewing and cognitive tasks using NIRS By chewing, oxy-Hb increased in the temporal area(Brodmann's Area 9 and 46) and decreased in the region of parietal By doing verbal fluency task, decreases of oxy-Hb in the regions of the frontal and parietal were observed. We can suppose that there is a similarity of activation area between the two tasks.

最近，一些研究人员报告说，咀嚼能力受损是痴呆症的触发因素之一。但是，只有少数关于咀嚼和认知功能之间关系的研究。这项研究的目的是研究咀嚼和血液动力学之间的关系，这是我们的医疗保健和预防某些神经系统疾病的第一步。首先，我们研究了对脑灌注的选择性监测，我们研究了测量光学信号的一些特征从近红外光谱法（NIR）的人头，它比其他方法具有一些优势，例如，坐在座椅上的测量值。我们阐明了NIR（时间分辨光谱法）对监测脑血液动力学的有用性和局限性。邻次检查，我们检查了HB浓度变化的变化因咀嚼而通过咀嚼而通过NIR进行咀嚼和认知任务，氧气中的Oxy-HB在临时区域中增加（Brodmann的临时区域（Brodmann's）区域9和46），通过做口头流利的任务在顶叶区域减少，观察到额叶和顶叶区域中的氧hb减少。我们可以假设两个任务之间的激活区域相似。

项目成果

Estimation of absorption coefficient of two-ayered turbid media by dividing of temporal profile of photon intensity in TRS measurement

TRS测量中光子强度时间分布的划分估计两层混浊介质的吸收系数

• 发表时间: 2005
• 作者: Sato C;et. al.
• 通讯作者: et. al.

Extraction of depth-dependent signals from time-resolved reflectance in Layered turbid media.

从层状混浊介质中的时间分辨反射率中提取与深度相关的信号。

• 发表时间: 2005
• 期刊: J, Biomed. Opt. 10(6)
• 作者: Sato C;et. al.
• 通讯作者: et. al.

Intraoperative monitoring of depth dependent hemoglobin concentration changes during CEAby time resolved reflectance.

术中通过时间分辨反射率监测 CEA 期间深度依赖性血红蛋白浓度变化。

• 发表时间: 2006
• 作者: Sato C;et. al.
• 通讯作者: et. al.

Estimation of absorption coefficient in bottom regions in multi-layered turbid media based on the time-domain depth sensitivity:a Monte Carloinvestigation.

基于时域深度敏感性的多层浑浊介质底部区域吸收系数估计：蒙特卡罗研究。

• 发表时间: 2008
• 期刊: SPIE Proceeding 6864
• 作者: Sato C;et. al.
• 通讯作者: et. al.

Extraction of depth dependent signals from time resolved reflectance in two-layered turbid media.

从两层浑浊介质中的时间分辨反射率中提取深度相关信号。

• 发表时间: 2005
• 作者: Sato C;et. al.
• 通讯作者: et. al.