Long-term prevention of oxidation of bioactive material using three-dimensional regeneration reaction of antioxidant with catechin

利用抗氧化剂与儿茶素的三维再生反应长期防止生物活性物质氧化

基本信息

批准号：
16360388
负责人：
YONEMOTO Toshikuni
金额：
$ 9.66万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16360388/
关键词：
bioactive material prevention of oxidation antioxidant β-carotene vitaminE vitaminC catechin kinetic model 油水二相系 β-カロチン

项目摘要

In this research, a high-speed regeneration cycle of antioxidants was designed by combining an amphiphilic catechin with a lipophilic vitamin E and a hydrophilic vitamin C for the purpose of long-term prevention of f3-carotene oxidation in the food system. In the presence of vitamin E and C, the following things were clarified: 1) the carotene oxidation was prevented as long as vitamin E existed in the system, 2) vitamin C was related to two contrastive reactions consuming and regenerating vitamin E, 3) the prevention period of carotene oxidation significantly increased under specific conditions. Conventionally the regeneration reaction of vitamin E by vitamin C was considered to contribute the increase of the prevention period. However, oxygen in the system was clarified to be almost consumed by the oxidation of vitamin C itself and consequently the carotene oxidation was prevented. The novel kinetic model considering the reaction mechanisms of carotene, vitamin E and C well described the contrastive effects progressing or preventing the carotene oxidation according to the amounts of vitamin C and oxygen in the system. On the other hand, the following things were clarified in the presence of catechin: 1) catechin was related to two contrastive reactions consuming carotene and preventing the carotene oxidation and 2) the structure of catechin was controlled which reaction preferentially occurred.

在这项研究中，通过将两亲性儿茶素与亲脂性维生素E和亲水性维生素C结合设计了抗氧化剂的高速再生循环，以长期防止食品系统中的f3-胡萝卜素氧化。在维生素E和C存在的情况下，澄清了以下问题：1）只要系统中存在维生素E，就可以防止胡萝卜素氧化，2）维生素C与消耗和再生维生素E的两种对比反应有关，3）在特定条件下，胡萝卜素氧化的预防期显着延长。以往认为维生素C对维生素E的再生反应有助于预防期的延长。然而，系统中的氧气被澄清为几乎被维生素C本身的氧化消耗掉，从而阻止了胡萝卜素的氧化。考虑胡萝卜素、维生素E和C的反应机制的新动力学模型很好地描述了根据系统中维生素C和氧气的量促进或阻止胡萝卜素氧化的对比效果。另一方面，在儿茶素存在的情况下，澄清了以下几点：1）儿茶素与消耗胡萝卜素和防止胡萝卜素氧化的两个对比反应有关，2）儿茶素的结构受到控制，优先发生反应。